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Olatunji LA, Soladoye AO. Low dietary folate impairs glucose tolerance and plasma lipid profile in oral contraceptive-treated rats. Pathophysiology. 2008;15(3):167-71doi: 10.1016/j.pathophys.2008.04.001.
Olatunji, L. A., & Soladoye, A. O. (2008). Low dietary folate impairs glucose tolerance and plasma lipid profile in oral contraceptive-treated rats. Pathophysiology : the official journal of the International Society for Pathophysiology, 15(3), 167-71. https://doi.org/10.1016/j.pathophys.2008.04.001
Olatunji, L A, and Soladoye, A O. "Low dietary folate impairs glucose tolerance and plasma lipid profile in oral contraceptive-treated rats." Pathophysiology : the official journal of the International Society for Pathophysiology vol. 15,3 (2008): 167-71. doi: https://doi.org/10.1016/j.pathophys.2008.04.001
Olatunji LA, Soladoye AO. Low dietary folate impairs glucose tolerance and plasma lipid profile in oral contraceptive-treated rats. Pathophysiology. 2008 Oct;15(3):167-71. doi: 10.1016/j.pathophys.2008.04.001. Epub 2008 Jun 24. PMID: 18572393.
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Pathophysiology. 2008 Oct;15(3):167-71. doi: 10.1016/j.pathophys.2008.04.001. Epub 2008 Jun 24.

Low dietary folate impairs glucose tolerance and plasma lipid profile in oral contraceptive-treated rats.

Pathophysiology : the official journal of the International Society for Pathophysiology

L A Olatunji, A O Soladoye

Affiliations

  1. Department of Physiology, College of Health Sciences, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria.

PMID: 18572393 DOI: 10.1016/j.pathophys.2008.04.001

Abstract

UNLABELLED: Estrogen-progestogen oral contraceptive (OC) use is associated with abnormal lipid metabolism, impaired glucose tolerance and high prevalence of vascular complications. OC use has been shown to alter the requirements for folic acid. Therefore, the aim of the present study was to clarify the influence of dietary folic acid on OC-induced impaired glucose tolerance and abnormal plasma lipid profile in female Sprague-Dawley rats. Vehicle-treated and OC-treated rats were fed for 6 weeks with a control diet (750mug folic acid/kg diet) while OC-treated folic acid deficient (FD) rats were fed for 6 weeks with a folic acid-deficient diet (250mug folic acid/kg diet). OC receiving rats were treated with a combination of OC steroids (ethinyl estradiol and norgestrel) by oral gavage. OC treatment resulted in rats receiving folic acid deficient diet in impaired glucose tolerance, decreased high-density lipoprotein (HDL)-cholesterol and increased low-density lipoprotein (LDL)-cholesterol when compared with control rats. However, OC treatment did not result in impaired glucose tolerance or disturbed plasma lipid profile in rats receiving the same folic acid level as the controls. OC treatment led to significant decreases in plasma levels of 17beta-estradiol and testosterone in both groups. OC administration in rats with folic acid deficient diet significantly lower HDL-cholesterol and higher LDL-cholesterol levels while plasma levels of 17beta-estradiol and testosterone were similar in both OC-treated groups.

CONCLUSION: These results demonstrate impaired glucose tolerance and disturbed plasma lipid profile induced by OC treatment in folic acid deficient rats and suggest that inadequate folic acid intake might contribute to increased cardiovascular risk during OC use that could be prevented by proper oral folic acid intake.

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