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Nielsen J, Pedersen AG, Strudsholm K, et al. Modeling fermentations with recombinant microorganisms: formulation of a structured model. Biotechnol Bioeng. 1991;37(9):802-8doi: 10.1002/bit.260370903.
Nielsen, J., Pedersen, A. G., Strudsholm, K., & Villadsen, J. (1991). Modeling fermentations with recombinant microorganisms: formulation of a structured model. Biotechnology and bioengineering, 37(9), 802-8. https://doi.org/10.1002/bit.260370903
Nielsen, J, et al. "Modeling fermentations with recombinant microorganisms: formulation of a structured model." Biotechnology and bioengineering vol. 37,9 (1991): 802-8. doi: https://doi.org/10.1002/bit.260370903
Nielsen J, Pedersen AG, Strudsholm K, Villadsen J. Modeling fermentations with recombinant microorganisms: formulation of a structured model. Biotechnol Bioeng. 1991 Apr 15;37(9):802-8. doi: 10.1002/bit.260370903. PMID: 18600679.
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Biotechnol Bioeng. 1991 Apr 15;37(9):802-8. doi: 10.1002/bit.260370903.

Modeling fermentations with recombinant microorganisms: formulation of a structured model.

Biotechnology and bioengineering

J Nielsen, A G Pedersen, K Strudsholm, J Villadsen

Affiliations

  1. Department of Biotechnology, Technical University of Denmark, DK-2800 Lyngby.

PMID: 18600679 DOI: 10.1002/bit.260370903

Abstract

A simple structured model is described and compared with experimental data for fermentations with recombinant. Escherichia coli. The model is a so-called compartment, model, where the different biomass components are lumped together in a few intracellular variables. The model is able to describe, in a biologically reasonable fashion, a majority of the observations that have been made through fermentations with recombinant microorganisms. The model is especially suited for description of dynamic changes in plasmid copy number, e.g., runaway plasmid replication.

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