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Monk KR, Wu J, Williams JP, et al. Mast cells can contribute to axon-glial dissociation and fibrosis in peripheral nerve. Neuron Glia Biol. 2007;3(3):233-44doi: 10.1017/S1740925X08000021.
Monk, K. R., Wu, J., Williams, J. P., Finney, B. A., Fitzgerald, M. E., Filippi, M. D., & Ratner, N. (2007). Mast cells can contribute to axon-glial dissociation and fibrosis in peripheral nerve. Neuron glia biology, 3(3), 233-44. https://doi.org/10.1017/S1740925X08000021
Monk, Kelly R, et al. "Mast cells can contribute to axon-glial dissociation and fibrosis in peripheral nerve." Neuron glia biology vol. 3,3 (2007): 233-44. doi: https://doi.org/10.1017/S1740925X08000021
Monk KR, Wu J, Williams JP, Finney BA, Fitzgerald ME, Filippi MD, Ratner N. Mast cells can contribute to axon-glial dissociation and fibrosis in peripheral nerve. Neuron Glia Biol. 2007 Aug;3(3):233-44. doi: 10.1017/S1740925X08000021. PMID: 18634614; PMCID: PMC2561270.
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Neuron Glia Biol. 2007 Aug;3(3):233-44. doi: 10.1017/S1740925X08000021.

Mast cells can contribute to axon-glial dissociation and fibrosis in peripheral nerve.

Neuron glia biology

Kelly R Monk, Jianqiang Wu, Jon P Williams, Brenda A Finney, Maureen E Fitzgerald, Marie-Dominique Filippi, Nancy Ratner

Affiliations

  1. 1Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, 3333 Burnet Avenue, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.

PMID: 18634614 PMCID: PMC2561270 DOI: 10.1017/S1740925X08000021

Abstract

Expression of the human epidermal growth factor receptor (EGFR) in murine Schwann cells results in loss of axon-Schwann cell interactions and collagen deposition, modeling peripheral nerve response to injury and tumorigenesis. Mast cells infiltrate nerves in all three situations. We show that mast cells are present in normal mouse peripheral nerve beginning at 4 weeks of age, and that the number of mast-cells in EGFR(+) nerves increases abruptly at 5-6 weeks of age as axons and Schwann cells dissociate. The increase in mast cell number is preceded and accompanied by elevated levels of mRNAs encoding the mast-cell chemoattractants Rantes, SCF and VEGF. Genetic ablation of mast cells and bone marrow reconstitution in W(41) x EGFR(+) mice indicate a role for mast cells in loss of axon-Schwann cell interactions and collagen deposition. Pharmacological stabilization of mast cells by disodium cromoglycate administration to EGFR(+) mice also diminished loss of axon-Schwann cell interaction. Together these three lines of evidence support the hypothesis that mast cells can contribute to alterations in peripheral nerves.

References

  1. Nat Neurosci. 2003 Nov;6(11):1186-93 - PubMed
  2. Histol Histopathol. 2004 Jan;19(1):259-70 - PubMed
  3. Genes Dev. 1999 Jun 1;13(11):1382-97 - PubMed
  4. J Neurosci Res. 1994 Feb 15;37(3):415-32 - PubMed
  5. Exp Hematol. 1983 Jul;11(6):452-60 - PubMed
  6. J Clin Invest. 2000 May;105(9):1233-41 - PubMed
  7. Nat Genet. 2001 Jul;28(3):294-6 - PubMed
  8. Neuron. 1994 Mar;12(3):509-27 - PubMed
  9. Dev Biol. 2002 Jun 15;246(2):245-58 - PubMed
  10. J Immunol. 2003 Oct 15;171(8):4385-91 - PubMed
  11. Cancer Cell. 2005 May;7(5):411-23 - PubMed
  12. Cancer Cell. 2005 Jan;7(1):65-75 - PubMed
  13. Nature. 2004 Sep 23;431(7007):405-6 - PubMed
  14. Annu Rev Immunol. 2005;23:749-86 - PubMed
  15. Am J Pathol. 2006 May;168(5):1686-96 - PubMed
  16. Exp Dermatol. 2003 Dec;12(6):886-910 - PubMed
  17. Genes Chromosomes Cancer. 1999 Mar;24(3):283-5 - PubMed
  18. Curr Drug Targets Inflamm Allergy. 2005 Feb;4(1):9-11 - PubMed
  19. Nature. 1961 Mar 4;189:766-7 - PubMed
  20. J Neurosci Res. 1994 Jun 15;38(3):243-7 - PubMed
  21. Exp Neurol. 1981 Oct;74(1):170-86 - PubMed
  22. Immunology. 1995 Nov;86(3):427-33 - PubMed
  23. Ann Allergy. 1976 Aug;37(2):123-5 - PubMed
  24. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3739-43 - PubMed
  25. Arch Neurol. 1965 Oct;13(4):372-82 - PubMed
  26. J Neuropathol Exp Neurol. 1997 Jun;56(6):627-40 - PubMed
  27. J Immunol. 2005 Mar 15;174(6):3626-32 - PubMed
  28. J Neurocytol. 2003 May;32(4):373-80 - PubMed
  29. Arch Dermatol. 1993 May;129(5):577-81 - PubMed
  30. J Clin Invest. 2003 Dec;112(12):1851-61 - PubMed
  31. Science. 2002 Sep 6;297(5587):1689-92 - PubMed
  32. J Neurosci. 2004 Oct 20;24(42):9250-60 - PubMed
  33. Nat Rev Immunol. 2006 Mar;6(3):218-30 - PubMed
  34. EMBO J. 1990 Jun;9(6):1805-13 - PubMed
  35. J Exp Med. 2001 Jul 2;194(1):F1-5 - PubMed
  36. Acta Neurol Scand. 1971;47(3):357-68 - PubMed
  37. Am J Epidemiol. 2000 Jan 1;151(1):33-40 - PubMed
  38. J Neuropathol Exp Neurol. 2005 Jan;64(1):1-9 - PubMed
  39. Proc Natl Acad Sci U S A. 1986 Jun;83(11):4094-8 - PubMed
  40. Genes Dev. 1990 Mar;4(3):390-400 - PubMed
  41. Arch Dermatol. 1987 Aug;123(8):1011-6 - PubMed
  42. Am J Physiol Heart Circ Physiol. 2004 May;286(5):H1750-6 - PubMed
  43. Cancer Res. 2002 Aug 1;62(15):4507-13 - PubMed

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