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Favre J, Deruaz JP, Uske A, et al. Skull base chordomas: presentation of six cases and review of the literature. J Clin Neurosci. 1994;1(1):7-18doi: 10.1016/0967-5868(94)90004-3.
Favre, J., Deruaz, J. P., Uske, A., & de Tribolet, N. (1994). Skull base chordomas: presentation of six cases and review of the literature. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 1(1), 7-18. https://doi.org/10.1016/0967-5868(94)90004-3
Favre, J, et al. "Skull base chordomas: presentation of six cases and review of the literature." Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia vol. 1,1 (1994): 7-18. doi: https://doi.org/10.1016/0967-5868(94)90004-3
Favre J, Deruaz JP, Uske A, de Tribolet N. Skull base chordomas: presentation of six cases and review of the literature. J Clin Neurosci. 1994 Jan;1(1):7-18. doi: 10.1016/0967-5868(94)90004-3. PMID: 18638720.
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J Clin Neurosci. 1994 Jan;1(1):7-18. doi: 10.1016/0967-5868(94)90004-3.

Skull base chordomas: presentation of six cases and review of the literature.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

J Favre, J P Deruaz, A Uske, N de Tribolet

Affiliations

  1. Neurosurgical Service, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

PMID: 18638720 DOI: 10.1016/0967-5868(94)90004-3

Abstract

Chordomas are uncommon tumours occuring from remnants of the notochord. They are mainly localized in the sacrococcygium, the spine and the skull base. We focused our study on skull base chordomas and reviewed 531 published cases and 6 cases diagnosed in our institution. The six cases diagnosed at our hospital are described with a special mention of a unique case presenting with meningitis. Clinical features, radiology, histopathology and survival with different treatments are reviewed. Skull base chordomas can occur at any age and are slightly more frequent in males. Patients complain most often of diplopia and headaches. Abducens nerve palsy is the commonest neurological finding. Radiological examination should include both CT-scan which shows extensive osteolysis, calcifications and contrast enhancement and MRI for topographical definition. Metastases rarely occur. Treatment remains controversial but combined surgery and radiotherapy is the best treatment with a 5 year survival rate of 75%.

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