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Schlachterman A, Valle F, Wall KM, et al. Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model. Transl Oncol. 2008;1(1):19-27doi: 10.1593/tlo.07100.
Schlachterman, A., Valle, F., Wall, K. M., Azios, N. G., Castillo, L., Morell, L., Washington, A. V., Cubano, L. A., & Dharmawardhane, S. F. (2008). Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model. Translational oncology, 1(1), 19-27. https://doi.org/10.1593/tlo.07100
Schlachterman, Alexander, et al. "Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model." Translational oncology vol. 1,1 (2008): 19-27. doi: https://doi.org/10.1593/tlo.07100
Schlachterman A, Valle F, Wall KM, Azios NG, Castillo L, Morell L, Washington AV, Cubano LA, Dharmawardhane SF. Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model. Transl Oncol. 2008 Mar;1(1):19-27. doi: 10.1593/tlo.07100. PMID: 18607509; PMCID: PMC2510765.
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Transl Oncol. 2008 Mar;1(1):19-27. doi: 10.1593/tlo.07100.

Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model.

Translational oncology

Alexander Schlachterman, Felix Valle, Kristin M Wall, Nicolas G Azios, Linette Castillo, Lymar Morell, A Valance Washington, Luis A Cubano, Surangani F Dharmawardhane

Affiliations

  1. Department of Anatomy and Cell Biology, Universidad Central del Caribe School of Medicine, Bayamon, PR 00960, USA.

PMID: 18607509 PMCID: PMC2510765 DOI: 10.1593/tlo.07100

Abstract

Grape polyphenols can act as antioxidants, antiangiogenics, and selective estrogen receptor (ER) modifiers and are therefore especially relevant for gynecological cancers such as breast cancer. The major polyphenols of red wine (resveratrol, quercetin, and catechin) have been individually shown to have anticancer properties. However, their combinatorial effect on metastatic breast cancers has not been investigated in vivo. We tested the effect of low dietary concentrations of resveratrol, quercetin, and catechin on breast cancer progression in vitro by analyzing cell proliferation and cell cycle progression. The effects of these compounds on fluorescently tagged breast tumor growth in nude mice were assessed using in situ fluorescence image analysis. Individual polyphenols at 0.5 microM neither decreased breast cancer cell proliferation nor affected cell cycle progression in vitro. However, a combination of resveratrol, quercetin, and catechin at 0.5, 5, or 20 microM each significantly reduced cell proliferation and blocked cell cycle progression in vitro. Furthermore, using in situ image analysis, we determined that combined dietary polyphenols at 0.5, 5, or 25 mg/kg reduced primary tumor growth of breast cancer xenografts in a nude mouse model. Peak inhibition was observed at 5 mg/kg. These results indicate that grape polyphenols may inhibit breast cancer progression.

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