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Buxton TL, Caruso JA. Sulpholane as a solvent for titration of barbiturates and sulpha drugs. Talanta. 1973;20(2):254-6doi: 10.1016/0039-9140(73)80281-4.
Buxton, T. L., & Caruso, J. A. (1973). Sulpholane as a solvent for titration of barbiturates and sulpha drugs. Talanta, 20(2), 254-6. https://doi.org/10.1016/0039-9140(73)80281-4
Buxton, T L, and Caruso, J A. "Sulpholane as a solvent for titration of barbiturates and sulpha drugs." Talanta vol. 20,2 (1973): 254-6. doi: https://doi.org/10.1016/0039-9140(73)80281-4
Buxton TL, Caruso JA. Sulpholane as a solvent for titration of barbiturates and sulpha drugs. Talanta. 1973 Feb;20(2):254-6. doi: 10.1016/0039-9140(73)80281-4. PMID: 18961269.
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Talanta. 1973 Feb;20(2):254-6. doi: 10.1016/0039-9140(73)80281-4.

Sulpholane as a solvent for titration of barbiturates and sulpha drugs.

Talanta

T L Buxton, J A Caruso

Affiliations

  1. Department of Chemistry University of Cincinnati Cincinnati, Ohio 45221, U.S.A.

PMID: 18961269 DOI: 10.1016/0039-9140(73)80281-4

Abstract

Sulpholane (tetramethylenesulphone) has been used as the medium for non-aqueous potentiometric titration of barbiturates and sulpha drugs with tetrabutylammonium hydroxide. Recoveries for 0.1-0.3 mmole of barbituric acid, phenobarbital, amobarbital, barbital, secobarbital, sulphapyridine, sulphadiazine and sulphamerazine were generally in the range 99-101%. A glass-calomel electrode system was used: common acid-base indicators give no colour change in the medium used.

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