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Hassan SS, Zaki MT, Eldesouki MH. Determination of penicillins by desulphurization with lead and edta titration. Talanta. 1979;26(2):91-5doi: 10.1016/0039-9140(79)80223-4.
Hassan, S. S., Zaki, M. T., & Eldesouki, M. H. (1979). Determination of penicillins by desulphurization with lead and edta titration. Talanta, 26(2), 91-5. https://doi.org/10.1016/0039-9140(79)80223-4
Hassan, S S, et al. "Determination of penicillins by desulphurization with lead and edta titration." Talanta vol. 26,2 (1979): 91-5. doi: https://doi.org/10.1016/0039-9140(79)80223-4
Hassan SS, Zaki MT, Eldesouki MH. Determination of penicillins by desulphurization with lead and edta titration. Talanta. 1979 Feb;26(2):91-5. doi: 10.1016/0039-9140(79)80223-4. PMID: 18962387.
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Talanta. 1979 Feb;26(2):91-5. doi: 10.1016/0039-9140(79)80223-4.

Determination of penicillins by desulphurization with lead and edta titration.

Talanta

S S Hassan, M T Zaki, M H Eldesouki

Affiliations

  1. Research Microanalytical Laboratory, Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.

PMID: 18962387 DOI: 10.1016/0039-9140(79)80223-4

Abstract

A new, simple, accurate and rapid method is described for the determination of total penicillins in pharmaceutical preparations. The method is based on desulphurization with potassium plumbite whereby one mole of lead sulphide is formed per mole of penicillin. The excess of lead ions is titrated with EDTA at pH 4.5, with use of the lead ion-selective electrode. Results are reproducible within +/- 0.5% and compare favourably with those obtained by the procedures of the United States and British Pharmacopoeias.

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