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Nuñez-Vergara LJ, Squella JA, Silva MM. Polarography of an acidic degradation product from cephalexin. Talanta. 1982;29(2):137-8doi: 10.1016/0039-9140(82)80036-2.
Nuñez-Vergara, L. J., Squella, J. A., & Silva, M. M. (1982). Polarography of an acidic degradation product from cephalexin. Talanta, 29(2), 137-8. https://doi.org/10.1016/0039-9140(82)80036-2
Nuñez-Vergara, L J, et al. "Polarography of an acidic degradation product from cephalexin." Talanta vol. 29,2 (1982): 137-8. doi: https://doi.org/10.1016/0039-9140(82)80036-2
Nuñez-Vergara LJ, Squella JA, Silva MM. Polarography of an acidic degradation product from cephalexin. Talanta. 1982 Feb;29(2):137-8. doi: 10.1016/0039-9140(82)80036-2. PMID: 18963099.
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Talanta. 1982 Feb;29(2):137-8. doi: 10.1016/0039-9140(82)80036-2.

Polarography of an acidic degradation product from cephalexin.

Talanta

L J Nuñez-Vergara, J A Squella, M M Silva

Affiliations

  1. Department of Chemical Pharmacology and Physical Chemistry, Faculty of Chemical and Pharmacological Sciences, University of Chile, P.O. Box 233, Santiago, Chile.

PMID: 18963099 DOI: 10.1016/0039-9140(82)80036-2

Abstract

2-Hydroxy-3-phenyl-6-methylpyrazine is identified as the product obtained by acidic degradation of cephalexin in the presence of formaldehyde. In 5M hydrochloric acid this product gives a well-defined reduction wave with a half-wave potential of -0.45 V vs. SCE. The wave is irreversible and diffusion-controlled. The diffusion current shows a linear relation with the cephalexin concentration and can be used for determination of cephalexin in plasma.

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