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Yost RA, Perchalski RJ, Brotherton HO, et al. Pharmaceutical and clinical analysis by tandem mass spectrometry. Talanta. 1984;31(10):929-35doi: 10.1016/0039-9140(84)80223-4.
Yost, R. A., Perchalski, R. J., Brotherton, H. O., Johnson, J. V., & Budd, M. B. (1984). Pharmaceutical and clinical analysis by tandem mass spectrometry. Talanta, 31(10), 929-35. https://doi.org/10.1016/0039-9140(84)80223-4
Yost, R A, et al. "Pharmaceutical and clinical analysis by tandem mass spectrometry." Talanta vol. 31,10 (1984): 929-35. doi: https://doi.org/10.1016/0039-9140(84)80223-4
Yost RA, Perchalski RJ, Brotherton HO, Johnson JV, Budd MB. Pharmaceutical and clinical analysis by tandem mass spectrometry. Talanta. 1984 Oct;31(10):929-35. doi: 10.1016/0039-9140(84)80223-4. PMID: 18963770.
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Talanta. 1984 Oct;31(10):929-35. doi: 10.1016/0039-9140(84)80223-4.

Pharmaceutical and clinical analysis by tandem mass spectrometry.

Talanta

R A Yost, R J Perchalski, H O Brotherton, J V Johnson, M B Budd

Affiliations

  1. Department of Chemistry, University of Florida, Gainesville, FL 32611, USA.

PMID: 18963770 DOI: 10.1016/0039-9140(84)80223-4

Abstract

Tandem mass spectrometry (MS/MS) is a promising technique for trace determination of compounds in complex mixtures. The application of triple-quadrupole MS/MS to clinical and pharmacological studies has been investigated with major emphasis on rapid screening and determination of drugs and biomolecules in physiological fluids and tissues. These techniques have been applied to a range of problems, including the determination of chlorinated compounds in humans, subpicogram analysis of neurochemicals and the detection of illegal drugs in racing animals. A new technique for determining the structures of all the metabolites of a particular drug has also been developed. It is possible to identify in a single sample all molecular ions which contain substructures characteristic of the parent drug. The structure of each metabolite can then be determined by obtaining the MS/MS spectrum of the molecular ion.

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