Display options
Cite
Issa AS, Mahrous MS, Salam MA, et al. The use of 2,3-dichloro-5,6-dicyano-p-benzoquinone for the spectrophotometric determination of some cardiovascular drugs. Talanta. 1987;34(7):670-2doi: 10.1016/0039-9140(87)80087-5.
Issa, A. S., Mahrous, M. S., Salam, M. A., & Soliman, N. (1987). The use of 2,3-dichloro-5,6-dicyano-p-benzoquinone for the spectrophotometric determination of some cardiovascular drugs. Talanta, 34(7), 670-2. https://doi.org/10.1016/0039-9140(87)80087-5
Issa, A S, et al. "The use of 2,3-dichloro-5,6-dicyano-p-benzoquinone for the spectrophotometric determination of some cardiovascular drugs." Talanta vol. 34,7 (1987): 670-2. doi: https://doi.org/10.1016/0039-9140(87)80087-5
Issa AS, Mahrous MS, Salam MA, Soliman N. The use of 2,3-dichloro-5,6-dicyano-p-benzoquinone for the spectrophotometric determination of some cardiovascular drugs. Talanta. 1987 Jul;34(7):670-2. doi: 10.1016/0039-9140(87)80087-5. PMID: 18964385.
Copy Download .nbib Format: NLM
Share it on

Talanta. 1987 Jul;34(7):670-2. doi: 10.1016/0039-9140(87)80087-5.

The use of 2,3-dichloro-5,6-dicyano-p-benzoquinone for the spectrophotometric determination of some cardiovascular drugs.

Talanta

A S Issa, M S Mahrous, M A Salam, N Soliman

Affiliations

  1. Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt.

PMID: 18964385 DOI: 10.1016/0039-9140(87)80087-5

Abstract

Some basic cardiovascular drugs containing secondary or tertiary amino groups are determined spectrophotometrically. The method is simple and sensitive; it is based on the interaction of the drugs, as n-electron donors, with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) as a pi-acceptor. The highly coloured radical anion exhibits maximum absorption at 460 nm. The drugs determined are pindolol, dipyridamole, hydralazine hydrochloride, quinidine sulphate, prenylamine lactate and tolazoline hydrochloride. Beer's law is obeyed for these drugs. The procedure is sensitive enough to permit unit dose assay of the individual drugs in their pharmaceutical formulations. The assay results are in accord with the pharmacopoeial assay results.

Publication Types