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Gallagher PA, Danielson ND. Colorimetric determination of macrolide antibiotics using ferric ion. Talanta. 1995;42(10):1425-32doi: 10.1016/0039-9140(95)98348-j.
Gallagher, P. A., & Danielson, N. D. (1995). Colorimetric determination of macrolide antibiotics using ferric ion. Talanta, 42(10), 1425-32. https://doi.org/10.1016/0039-9140(95)98348-j
Gallagher, P A, and Danielson, N D. "Colorimetric determination of macrolide antibiotics using ferric ion." Talanta vol. 42,10 (1995): 1425-32. doi: https://doi.org/10.1016/0039-9140(95)98348-j
Gallagher PA, Danielson ND. Colorimetric determination of macrolide antibiotics using ferric ion. Talanta. 1995 Oct;42(10):1425-32. doi: 10.1016/0039-9140(95)98348-j. PMID: 18966372.
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Talanta. 1995 Oct;42(10):1425-32. doi: 10.1016/0039-9140(95)98348-j.

Colorimetric determination of macrolide antibiotics using ferric ion.

Talanta

P A Gallagher, N D Danielson

Affiliations

  1. Department of Chemistry, Miami University, Oxford, OH 45056, USA.

PMID: 18966372 DOI: 10.1016/0039-9140(95)98348-j

Abstract

Macrolide antibiotics such as erythromycin, oleandomycin, spiromycin, and tylosin are found to react with Fe(3+) in the presence of an acetic acid-sulfuric acid mixture to form a colored product having a useful absorption band at 592 nm. Troleandomycin forms only a weakly colored product upon reaction. The molar absorptivity is about 2900 1 mol(-1) cm(-1) for erythromycin and the detection limit is 5 mug ml(-1). This colorimetric method permits the analysis of fermentation broths containing either erythromycin or tylosin without a separation step.

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