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Berzas JJ, Castañeda G, Pinilla MJ. Determination of Clobazam, Clorazepate, Flurazepam and Flunitrazepam in pharmaceutical preparations. Talanta. 2002;57(2):333-41doi: 10.1016/s0039-9140(02)00024-3.
Berzas, J. J., Castañeda, G., & Pinilla, M. J. (2002). Determination of Clobazam, Clorazepate, Flurazepam and Flunitrazepam in pharmaceutical preparations. Talanta, 57(2), 333-41. https://doi.org/10.1016/s0039-9140(02)00024-3
Berzas, J J, et al. "Determination of Clobazam, Clorazepate, Flurazepam and Flunitrazepam in pharmaceutical preparations." Talanta vol. 57,2 (2002): 333-41. doi: https://doi.org/10.1016/s0039-9140(02)00024-3
Berzas JJ, Castañeda G, Pinilla MJ. Determination of Clobazam, Clorazepate, Flurazepam and Flunitrazepam in pharmaceutical preparations. Talanta. 2002 May 16;57(2):333-41. doi: 10.1016/s0039-9140(02)00024-3. PMID: 18968634.
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Talanta. 2002 May 16;57(2):333-41. doi: 10.1016/s0039-9140(02)00024-3.

Determination of Clobazam, Clorazepate, Flurazepam and Flunitrazepam in pharmaceutical preparations.

Talanta

J J Berzas, G Castañeda, M J Pinilla

Affiliations

  1. Departamento de Quimica Analitica y Tecnologia de Alimentos, Facultad de Quimicas, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain.

PMID: 18968634 DOI: 10.1016/s0039-9140(02)00024-3

Abstract

The separation of four benzodiazepines (Flurazepam, Flunitrazepam, Clobazam and Clorazepate) in pharmaceutical products by micellar electrokinetic chromatography (MEKC) is described. It was carried out at 25 degrees C and 25 kV by using a 57 cm (50 cm to the detector)x75 mum i.d. fused silica capillary and a 15 mM borate buffer (pH 9.2), 35 mM sodium dodecylsulfate (SDS) and 35 mM sodium deoxycholate water solution. Under these conditions, the analysis was performed in 8 min with acceptable limits of quantification (between 3 and 5 mg l(-1)). The method has been applied for quantifying these benzodiazepines in serum and different commercial formulations with recoveries near 100%.

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