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Meloun M, Syrový T, Vrána A. The thermodynamic dissociation constants of ambroxol, antazoline, naphazoline, oxymetazoline and ranitidine by the regression analysis of spectrophotometric data. Talanta. 2004;62(3):511-22doi: 10.1016/j.talanta.2003.08.027.
Meloun, M., Syrový, T., & Vrána, A. (2004). The thermodynamic dissociation constants of ambroxol, antazoline, naphazoline, oxymetazoline and ranitidine by the regression analysis of spectrophotometric data. Talanta, 62(3), 511-22. https://doi.org/10.1016/j.talanta.2003.08.027
Meloun, Milan, et al. "The thermodynamic dissociation constants of ambroxol, antazoline, naphazoline, oxymetazoline and ranitidine by the regression analysis of spectrophotometric data." Talanta vol. 62,3 (2004): 511-22. doi: https://doi.org/10.1016/j.talanta.2003.08.027
Meloun M, Syrový T, Vrána A. The thermodynamic dissociation constants of ambroxol, antazoline, naphazoline, oxymetazoline and ranitidine by the regression analysis of spectrophotometric data. Talanta. 2004 Feb 27;62(3):511-22. doi: 10.1016/j.talanta.2003.08.027. PMID: 18969326.
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Talanta. 2004 Feb 27;62(3):511-22. doi: 10.1016/j.talanta.2003.08.027.

The thermodynamic dissociation constants of ambroxol, antazoline, naphazoline, oxymetazoline and ranitidine by the regression analysis of spectrophotometric data.

Talanta

Milan Meloun, Tomás Syrový, Ales Vrána

Affiliations

  1. Department of Analytical Chemistry, University of Pardubice, Namesti Cs. Legii 565, CZ-532 10 Pardubice, Czech Republic.

PMID: 18969326 DOI: 10.1016/j.talanta.2003.08.027

Abstract

The mixed dissociation constants of five drug acids-ambroxol, antazoline, naphazoline, oxymetazoline and ranitidine-at various ionic strengths I of range 0.01 and 1.0 and at temperatures of 25 and 37 degrees C were determined using SQUAD(84) regression analysis of the pH-spectrophotometric titration data. A proposed strategy of efficient experimentation in a protonation constants determination, followed by a computational strategy for the chemical model with a protonation constants determination, is presented on the protonation equilibria of ambroxol. The thermodynamic dissociation constant pK(a)(T) was estimated by non-linear regression of {pK(a), I} data at 25 and 37 degrees C: for ambroxol p K (a ,1)(T )=8.05 (6) and 8.25 (4), logbeta (21)(T )=11.67 (6) and 11.83 (8), for antazoline p K (a ,1)(T )=7.79 (2) and 7.83 (6), p K (a ,2)(T )=9.74 (3) and 9.55 (2), for naphazoline pK (a ,1)(T )=10.81 (1) and 10.63 (1), for oxymethazoline pK (a ,1)(T )=10.62 (2) and 10.77 (7), pK(a,2)(T)=12.03(3) and 11.82 (4) and for ranitidine p K (a ,1)(T )=1.89 (1) and 1.77 (1). Goodness-of-fit tests for various regression diagnostics enabled the reliability of the parameter estimates to be found.

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