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van Beuzekom AC, Hijman WC, Berkhoff CJ, et al. Fast sample preparation involving MASE and coupled column normal phase liquid chromatography for the rapid trace analysis of dioxins in air-dust samples from fire catastrophe emissions. Talanta. 2004;63(5):1183-91doi: 10.1016/j.talanta.2004.05.026.
van Beuzekom, A. C., Hijman, W. C., Berkhoff, C. J., Stoffelsen, B. H., den Boer, A. C., Groenemeijer, G. S., Mooibroek, D., Hoogerbrugge, R., Broekman, M. H., Baumann, R. A., & Hogendoorn, E. A. (2004). Fast sample preparation involving MASE and coupled column normal phase liquid chromatography for the rapid trace analysis of dioxins in air-dust samples from fire catastrophe emissions. Talanta, 63(5), 1183-91. https://doi.org/10.1016/j.talanta.2004.05.026
van Beuzekom, A C, et al. "Fast sample preparation involving MASE and coupled column normal phase liquid chromatography for the rapid trace analysis of dioxins in air-dust samples from fire catastrophe emissions." Talanta vol. 63,5 (2004): 1183-91. doi: https://doi.org/10.1016/j.talanta.2004.05.026
van Beuzekom AC, Hijman WC, Berkhoff CJ, Stoffelsen BH, den Boer AC, Groenemeijer GS, Mooibroek D, Hoogerbrugge R, Broekman MH, Baumann RA, Hogendoorn EA. Fast sample preparation involving MASE and coupled column normal phase liquid chromatography for the rapid trace analysis of dioxins in air-dust samples from fire catastrophe emissions. Talanta. 2004 Aug 08;63(5):1183-91. doi: 10.1016/j.talanta.2004.05.026. PMID: 18969547.
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Talanta. 2004 Aug 08;63(5):1183-91. doi: 10.1016/j.talanta.2004.05.026.

Fast sample preparation involving MASE and coupled column normal phase liquid chromatography for the rapid trace analysis of dioxins in air-dust samples from fire catastrophe emissions.

Talanta

A C van Beuzekom, W C Hijman, C J Berkhoff, B H G Stoffelsen, A C den Boer, G S Groenemeijer, D Mooibroek, R Hoogerbrugge, M H Broekman, R A Baumann, E A Hogendoorn

Affiliations

  1. Laboratory for Analytical Chemistry, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands.

PMID: 18969547 DOI: 10.1016/j.talanta.2004.05.026

Abstract

A new approach has been developed and tested for the urgent analysis of dioxins in samples of air-dust filters originating from catastrophe emissions. The procedure consists of a fast extraction of the sample with microwave solvent extraction (MASE) and acetone as solvent followed by a fast cleanup of the extract with normal phase coupled column liquid chromatography (LC/LC). The multi-dimensional LC/LC system employs a 50 mm x4.6 mm i.d. column packed with 3mum silica and a 150 mm x4.6 mm i.d. column packed with 5mum PYE as the first and second analytical column, respectively. Iso-hexane is used on both columns to perform cleanup and dichloromethane to perform efficient back-flush elution of the compounds from the second column. The obtained polarity-based separation in the first dimension and molecular-structure based separation in the second dimension provides a fast and powerful cleanup. Validation was done by analysing samples of homemade RIVM air-dust with aged residues (n=8, spiking level about 15pgmg(-1) per compound) of dioxins/furans and samples of reference Urban Dust SRM 1649a (n=4) with both the new approach and the existing conventional procedure and were instrumentally analyzed with capillary gas chromatography and high resolution mass spectrometric detection (GC/HRMS). In comparison to the existing conventional procedure, the new approach reduces sample processing from several days to several hours per sample. As regards the aged-residue air-dust samples, the new method shows a good accuracy, precision and high selectivity providing a performance in good agreement with the existing procedure. In SRM air-dust, the concentration of a few compounds obtained by the new method was below (10-50%) the certified value.

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