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Ali I, Naim L, Ghanem A, et al. Chiral separations of piperidine-2,6-dione analogues on Chiralpak IA and Chiralpak IB columns by using HPLC. Talanta. 2006;69(4):1013-7doi: 10.1016/j.talanta.2005.12.004.
Ali, I., Naim, L., Ghanem, A., & Aboul-Enein, H. Y. (2006). Chiral separations of piperidine-2,6-dione analogues on Chiralpak IA and Chiralpak IB columns by using HPLC. Talanta, 69(4), 1013-7. https://doi.org/10.1016/j.talanta.2005.12.004
Ali, Imran, et al. "Chiral separations of piperidine-2,6-dione analogues on Chiralpak IA and Chiralpak IB columns by using HPLC." Talanta vol. 69,4 (2006): 1013-7. doi: https://doi.org/10.1016/j.talanta.2005.12.004
Ali I, Naim L, Ghanem A, Aboul-Enein HY. Chiral separations of piperidine-2,6-dione analogues on Chiralpak IA and Chiralpak IB columns by using HPLC. Talanta. 2006 Jun 15;69(4):1013-7. doi: 10.1016/j.talanta.2005.12.004. Epub 2006 Jan 10. PMID: 18970673.
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Talanta. 2006 Jun 15;69(4):1013-7. doi: 10.1016/j.talanta.2005.12.004. Epub 2006 Jan 10.

Chiral separations of piperidine-2,6-dione analogues on Chiralpak IA and Chiralpak IB columns by using HPLC.

Talanta

Imran Ali, Lahoucine Naim, Ashraf Ghanem, Hassan Y Aboul-Enein

Affiliations

  1. National Institute of Hydrology, Roorkee 247667, India.

PMID: 18970673 DOI: 10.1016/j.talanta.2005.12.004

Abstract

Recently, two new immobilized polysaccharides based CSPs, namely tris-(3,5-dimethylphenylcarbamate) derivatives of amylose and cellulose known as Chiralpak IA and Chiralpak IB were introduced, which may be used with a wide range of solvents including standard and prohibited ones. Several racemic piperidine-2,6-dione analogues [aminoglutethimide, p-nitro-glutethimide, p-nitro-5-aminoglutethimide, cyclohexylaminoglutethimide, phenglutarimide and thalidomide] have been resolved on Chiralpak IA and Chiralpak IB columns (25cmx0.46cm). The non-conventional mobile phases used were methyl-tert-butyl ether-THF (90:10, v/v) [I], 100% dichloromethane [II] and 100% acetonitrile [III] separately at a flow rate of 1.0mL/min using a UV detector at 254nm. The resolution factors for Chiralpak IA and Chiralpak IB columns were 1.00-5.33 and 0.33-0.67, respectively. Chiralpak IA column gave better results than Chiralpak IB column for the reported molecules using the developed HPLC conditions. Experimental conditions and the possible chiral recognition mechanisms have been discussed.

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