Display options
Cite
Shilstein SSh, Cortesi M, Breskin A, et al. Prostatic Zn determination for prostate cancer diagnosis. Talanta. 2006;70(5):914-21doi: 10.1016/j.talanta.2006.05.053.
Shilstein, S. S. h., Cortesi, M., Breskin, A., Chechik, R., Vartsky, D., Raviv, G., Kleinman, N., Ramon, J., Kogan, G., Gladysh, V., Moriel, E., Huszar, M., Volkov, A., & Fridman, E. (2006). Prostatic Zn determination for prostate cancer diagnosis. Talanta, 70(5), 914-21. https://doi.org/10.1016/j.talanta.2006.05.053
Shilstein, S Sh, et al. "Prostatic Zn determination for prostate cancer diagnosis." Talanta vol. 70,5 (2006): 914-21. doi: https://doi.org/10.1016/j.talanta.2006.05.053
Shilstein SSh, Cortesi M, Breskin A, Chechik R, Vartsky D, Raviv G, Kleinman N, Ramon J, Kogan G, Gladysh V, Moriel E, Huszar M, Volkov A, Fridman E. Prostatic Zn determination for prostate cancer diagnosis. Talanta. 2006 Dec 15;70(5):914-21. doi: 10.1016/j.talanta.2006.05.053. Epub 2006 Jun 22. PMID: 18970860.
Copy Download .nbib Format: NLM
Share it on

Talanta. 2006 Dec 15;70(5):914-21. doi: 10.1016/j.talanta.2006.05.053. Epub 2006 Jun 22.

Prostatic Zn determination for prostate cancer diagnosis.

Talanta

S Sh Shilstein, M Cortesi, A Breskin, R Chechik, D Vartsky, G Raviv, N Kleinman, J Ramon, G Kogan, V Gladysh, E Moriel, M Huszar, A Volkov, E Fridman

Affiliations

  1. Department of Particle Physics, Weizmann Institute of Science, POB 26, Rehovot 76100, Israel.

PMID: 18970860 DOI: 10.1016/j.talanta.2006.05.053

Abstract

We present our studies of prostatic Zn concentration measurements, carried out in the light of a novel prostate cancer (CAP) diagnosis method proposed by us. The method is based on in vivo prostatic Zn mapping by XRF trans-rectal probe. We report on the extensive clinical studies, intended to assess the validity of the novel proposed diagnostic method. Zn content was measured in vitro in needle-biopsy samples from several hundreds of patients, and was correlated with histological findings and other patient parameters. For this purpose, a technique of absolute Zn content determination in approximately 1mm(3) fresh tissue samples by XRF was developed. The experimental details and the main clinical-evaluation results are presented. We further outline the suggested design of the XRF trans-rectal probe for an efficient in vivo detection and mapping of the Zn fluorescence radiation from the prostate through the rectal wall. Laboratory phantom studies, a preliminary design concept and its expected performance are also reported.

Publication Types