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Bonadio F, Margot P, Delémont O, et al. Headspace solid-phase microextraction (HS-SPME) and liquid-liquid extraction (LLE): comparison of the performance in classification of ecstasy tablets. Part 2. Forensic Sci Int. 2008;182(1):52-6doi: 10.1016/j.forsciint.2008.10.005.
Bonadio, F., Margot, P., Delémont, O., & Esseiva, P. (2008). Headspace solid-phase microextraction (HS-SPME) and liquid-liquid extraction (LLE): comparison of the performance in classification of ecstasy tablets. Part 2. Forensic science international, 182(1), 52-6. https://doi.org/10.1016/j.forsciint.2008.10.005
Bonadio, Federica, et al. "Headspace solid-phase microextraction (HS-SPME) and liquid-liquid extraction (LLE): comparison of the performance in classification of ecstasy tablets. Part 2." Forensic science international vol. 182,1 (2008): 52-6. doi: https://doi.org/10.1016/j.forsciint.2008.10.005
Bonadio F, Margot P, Delémont O, Esseiva P. Headspace solid-phase microextraction (HS-SPME) and liquid-liquid extraction (LLE): comparison of the performance in classification of ecstasy tablets. Part 2. Forensic Sci Int. 2008 Nov 20;182(1):52-6. doi: 10.1016/j.forsciint.2008.10.005. Epub 2008 Nov 07. PMID: 18995974.
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Forensic Sci Int. 2008 Nov 20;182(1):52-6. doi: 10.1016/j.forsciint.2008.10.005. Epub 2008 Nov 07.

Headspace solid-phase microextraction (HS-SPME) and liquid-liquid extraction (LLE): comparison of the performance in classification of ecstasy tablets. Part 2.

Forensic science international

Federica Bonadio, Pierre Margot, Olivier Delémont, Pierre Esseiva

Affiliations

  1. Ecole des Sciences Criminelles, Institut de Police Scientifique, University of Lausanne, Batochime, CH-1015 Lausanne-Dorigny, Switzerland.

PMID: 18995974 DOI: 10.1016/j.forsciint.2008.10.005

Abstract

Headspace solid-phase microextraction (HS-SPME) is assessed as an alternative to liquid-liquid extraction (LLE) currently used for 3,4-methylenedioxymethampethamine (MDMA) profiling. Both methods were compared evaluating their performance in discriminating and classifying samples. For this purpose 62 different seizures were analysed using both extraction techniques followed by gas chromatography-mass spectroscopy (GC-MS). A previously validated method provided data for HS-SPME, whereas LLE data were collected applying a harmonized methodology developed and used in the European project CHAMP. After suitable pre-treatment, similarities between sample pairs were studied using the Pearson correlation. Both methods enable to distinguish between samples coming from the same pre-tabletting batches and samples coming from different pre-tabletting batches. This finding emphasizes the use of HS-SPME as an effective alternative to LLE, with additional advantages such as sample preparation and a solvent-free process.

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