Display options
Cite
Vranic S, Caughron SK, Djuricic S, et al. Hamartomas, teratomas and teratocarcinosarcomas of the head and neck: Report of 3 new cases with clinico-pathologic correlation, cytogenetic analysis, and review of the literature. BMC Ear Nose Throat Disord. 2008;8:8doi: 10.1186/1472-6815-8-8.
Vranic, S., Caughron, S. K., Djuricic, S., Bilalovic, N., Zaman, S., Suljevic, I., Lydiatt, W. M., Emanuel, J., & Gatalica, Z. (2008). Hamartomas, teratomas and teratocarcinosarcomas of the head and neck: Report of 3 new cases with clinico-pathologic correlation, cytogenetic analysis, and review of the literature. BMC ear, nose, and throat disorders, 88. https://doi.org/10.1186/1472-6815-8-8
Vranic, Semir, et al. "Hamartomas, teratomas and teratocarcinosarcomas of the head and neck: Report of 3 new cases with clinico-pathologic correlation, cytogenetic analysis, and review of the literature." BMC ear, nose, and throat disorders vol. 8 (2008): 8. doi: https://doi.org/10.1186/1472-6815-8-8
Vranic S, Caughron SK, Djuricic S, Bilalovic N, Zaman S, Suljevic I, Lydiatt WM, Emanuel J, Gatalica Z. Hamartomas, teratomas and teratocarcinosarcomas of the head and neck: Report of 3 new cases with clinico-pathologic correlation, cytogenetic analysis, and review of the literature. BMC Ear Nose Throat Disord. 2008 Nov 24;8:8. doi: 10.1186/1472-6815-8-8. PMID: 19025657; PMCID: PMC2611960.
Copy Download .nbib Format: NLM
Share it on

BMC Ear Nose Throat Disord. 2008 Nov 24;8:8. doi: 10.1186/1472-6815-8-8.

Hamartomas, teratomas and teratocarcinosarcomas of the head and neck: Report of 3 new cases with clinico-pathologic correlation, cytogenetic analysis, and review of the literature.

BMC ear, nose, and throat disorders

Semir Vranic, Samuel K Caughron, Slavisa Djuricic, Nurija Bilalovic, Sadiq Zaman, Ismet Suljevic, William M Lydiatt, Jane Emanuel, Zoran Gatalica

Affiliations

  1. Department of Pathology, Clinical Center of the University of Sarajevo, Bosnia and Herzegovina. [email protected]

PMID: 19025657 PMCID: PMC2611960 DOI: 10.1186/1472-6815-8-8

Abstract

BACKGROUND: Germ-cell tumors (GCT) are a histologically and biologically diverse group of neoplasms which primarily occur in the gonads but also develop at different extragonadal sites in the midline of the body. The head and neck region including the upper respiratory tract is a very rare location for such tumors in both children and adults, which can cause diagnostic and therapeutic difficulties.

METHODS: We describe here two new cases of multilineage tumors including sinonasal teratocarcinosarcoma [SNTCS], and congenital oronasopharyngeal teratoma (epignathus) and compare their features with those of a new case of a rare salivary gland anlage tumor [SGAT], an entity for which the pathogenesis is unclear (i.e. hamartoma versus neoplasm). We correlate their presenting clinico-pathological features and compare histologic and cytogenetic features in an attempt to elucidate their pathogenesis and biologic potentials.

RESULTS AND DISCUSSION: Cytogenetic analysis revealed chromosomal abnormalities only in the case of SNTCS that showed trisomy 12 and 1p deletion. Both cytogenetic abnormalities are characteristically present in malignant germ cell tumors providing for the first time evidence that this rare tumor type indeed might represent a variant of a germ cell neoplasm. The SGAT and epignathus carried no such cytogenetic abnormalities, in keeping with their limited and benign biologic potential.

CONCLUSION: The comparison of these three cases should serve to emphasize the diversity of multilineage tumors (hamartomas and GCT) of the upper respiratory tract in regards to their biology, age of presentation and clinical outcomes. Malignant tumors of germ cell origins are more likely to affect adults with insidious symptom development, while benign tumors can nevertheless cause dramatic clinical symptoms which, under certain circumstances, can be fatal.

References

  1. Histopathology. 1998 Jan;32(1):84 - PubMed
  2. Cancer Genet Cytogenet. 2007 Apr 1;174(1):68-73 - PubMed
  3. Hum Pathol. 2008 Apr;39(4):605-9 - PubMed
  4. Am J Surg Pathol. 2007 Sep;31(9):1356-62 - PubMed
  5. J Laryngol Otol. 1985 Dec;99(12):1281-7 - PubMed
  6. Pathol Res Pract. 1995 Mar;191(2):166-71; discussion 172-3 - PubMed
  7. Genes Chromosomes Cancer. 2006 Nov;45(11):995-1006 - PubMed
  8. Pediatr Surg Int. 2003 Sep;19(7):509-19 - PubMed
  9. Int J Pediatr Otorhinolaryngol. 2005 Feb;69(2):149-56 - PubMed
  10. Cancer Genet Cytogenet. 1994 Jul 15;75(2):90-102 - PubMed
  11. Br J Oral Maxillofac Surg. 2007 Jun;45(4):326-7 - PubMed
  12. Radiographics. 2005 Jan-Feb;25(1):215-42 - PubMed
  13. Pediatr Blood Cancer. 2004 Nov;43(6):687-91 - PubMed
  14. Plast Reconstr Surg. 1993 Feb;91(2):223-8 - PubMed
  15. Pathol Int. 2000 Jan;50(1):71-5 - PubMed
  16. Nat Rev Cancer. 2005 Mar;5(3):210-22 - PubMed
  17. Cancer Genet Cytogenet. 1999 Nov;115(1):1-10 - PubMed
  18. Ann Diagn Pathol. 2006 Dec;10(6):339-42 - PubMed
  19. Arch Otolaryngol Head Neck Surg. 2008 Jun;134(6):592-5 - PubMed
  20. Am J Surg Pathol. 1994 Jan;18(1):25-36 - PubMed
  21. J Oral Maxillofac Surg. 2004 Mar;62(3):379-83 - PubMed
  22. Pathology. 1996 May;28(2):128-30 - PubMed
  23. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Apr;101(4):481-6 - PubMed
  24. J Matern Fetal Neonatal Med. 2006 Jun;19(6):377-9 - PubMed
  25. Genes Chromosomes Cancer. 1999 Jun;25(2):134-46 - PubMed
  26. Acta Otorrinolaringol Esp. 1991 Sep-Oct;42(5):363-7 - PubMed
  27. Br J Oral Maxillofac Surg. 2008 Jun;46(4):317-9 - PubMed
  28. Fetal Diagn Ther. 2003 Jan-Feb;18(1):26-8 - PubMed
  29. Ann Diagn Pathol. 2008 Dec;12(6):415-25 - PubMed
  30. Zhonghua Bing Li Xue Za Zhi. 2007 Aug;36(8):534-8 - PubMed
  31. J Pediatr Surg. 1998 Mar;33(3):520-1 - PubMed
  32. Pediatrics. 2003 Jul;112(1 Pt 1):e66-9 - PubMed
  33. Cancer. 1984 May 15;53(10):2140-54 - PubMed
  34. Klin Padiatr. 2006 Nov-Dec;218(6):296-302 - PubMed
  35. Prenat Diagn. 1993 Oct;13(10):945-52 - PubMed
  36. Cleft Palate Craniofac J. 2000 Jan;37(1):83-91 - PubMed
  37. Int J Pediatr Otorhinolaryngol. 2002 Feb 1;62(2):159-64 - PubMed

Publication Types