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Martínez Sánchez CR, Rojas Velasco G, Arias Mendoza A, et al. Combinación farmacológica en el tratamiento del infarto agudo del miocardio con elevación del segmento ST. Análisis de la literatura y experiencia en la Unidad Coronaria del Instituto Nacional de Cardiología "Dr. Ignacio Chávez". [Pharmacologic combination in the treatment of the acute myocardial infarction with ST elevation]. Arch Cardiol Mex. 2007;77:S4-23-30
Martínez Sánchez, C. R., Rojas Velasco, G., Arias Mendoza, A., & Reding García, J. M. (2007). Combinación farmacológica en el tratamiento del infarto agudo del miocardio con elevación del segmento ST. Análisis de la literatura y experiencia en la Unidad Coronaria del Instituto Nacional de Cardiología "Dr. Ignacio Chávez". [Pharmacologic combination in the treatment of the acute myocardial infarction with ST elevation]. Archivos de cardiologia de Mexico, 77S4-23-30.
Martínez Sánchez, Carlos Rodolfo, et al. "Combinación farmacológica en el tratamiento del infarto agudo del miocardio con elevación del segmento ST. Análisis de la literatura y experiencia en la Unidad Coronaria del Instituto Nacional de Cardiología "Dr. Ignacio Chávez"." [Pharmacologic combination in the treatment of the acute myocardial infarction with ST elevation]. Archivos de cardiologia de Mexico vol. 77 (2007): S4-23-30.
Martínez Sánchez CR, Rojas Velasco G, Arias Mendoza A, Reding García JM. Combinación farmacológica en el tratamiento del infarto agudo del miocardio con elevación del segmento ST. Análisis de la literatura y experiencia en la Unidad Coronaria del Instituto Nacional de Cardiología "Dr. Ignacio Chávez". [Pharmacologic combination in the treatment of the acute myocardial infarction with ST elevation]. Arch Cardiol Mex. 2007 Oct-Dec;77:S4-23-30. Spanish. PMID: 18938693.
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Arch Cardiol Mex. 2007 Oct-Dec;77:S4-23-30.

[Pharmacologic combination in the treatment of the acute myocardial infarction with ST elevation].

Archivos de cardiologia de Mexico

[Article in Spanish]
Carlos Rodolfo Martínez Sánchez, Gustavo Rojas Velasco, Alexandra Arias Mendoza, Jesús Martínez Reding García

Affiliations

  1. Urgencias y Unidad Coronaria, Instituto Nacional de Cardiologia "Ignacio Chávez", INCICH, Juan Badiano Núm. 1, Col. Sección XVI, Tlalpan 14080, México, DF. [email protected]

PMID: 18938693

Abstract

The evolution of reperfusion treatment has permitted an improvement in the prognosis and survival of patients with Acute myocardial infarction with ST elevation. The benefit of thrombolitic therapy was demonstrated clearly starting with the first trials of ISIS 2. It was also demonstrated this benefit is greater when the thrombolitic is combined with aspirin. Other trials have arisen like GUSTO I and TIMI 14, which have continued with the search for the best strategy of reperfusion, demonstrating that the pharmacologic combination with fibrinolitic, antiplatelet and antithrombinics provides the best results regarding permeability of the epicardic artery and transmiocardic reperfusion. Finally the mechanical reperfusion has managed to improve the results obtained with the pharmacologic treatment. Nevertheless it is probably that the Angioplasty with fibrinolitic and antiplatelet therapy is a useful treatment strategy, available for the patient with acute coronary syndrome with ST elevation. In light of the latest studies we must be very cautious, but based on the knowledge of the physiopathology of these syndromes, we think there is still much to discover.

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