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Biasi F, Mascia C, Poli G. TGFbeta1 expression in colonic mucosa: modulation by dietary lipids. Genes Nutr. 2007;2(2):233-43doi: 10.1007/s12263-007-0053-2.
Biasi, F., Mascia, C., & Poli, G. (2007). TGFbeta1 expression in colonic mucosa: modulation by dietary lipids. Genes & nutrition, 2(2), 233-43. https://doi.org/10.1007/s12263-007-0053-2
Biasi, Fiorella, et al. "TGFbeta1 expression in colonic mucosa: modulation by dietary lipids." Genes & nutrition vol. 2,2 (2007): 233-43. doi: https://doi.org/10.1007/s12263-007-0053-2
Biasi F, Mascia C, Poli G. TGFbeta1 expression in colonic mucosa: modulation by dietary lipids. Genes Nutr. 2007 Nov;2(2):233-43. doi: 10.1007/s12263-007-0053-2. Epub 2007 Sep 27. PMID: 18850178; PMCID: PMC2474948.
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Genes Nutr. 2007 Nov;2(2):233-43. doi: 10.1007/s12263-007-0053-2. Epub 2007 Sep 27.

TGFbeta1 expression in colonic mucosa: modulation by dietary lipids.

Genes & nutrition

Fiorella Biasi, Cinzia Mascia, Giuseppe Poli

Affiliations

  1. Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, 10043, Orbassano, Turin, Italy.

PMID: 18850178 PMCID: PMC2474948 DOI: 10.1007/s12263-007-0053-2

Abstract

Transforming growth factor beta1 (TGFbeta1) is fundamental to maintain the intestinal epithelial cell homeostasis through its control action on cell proliferation, differentiation and apoptosis. TGFbeta1 dysregulation has been observed in several chronic human diseases, including ulcerative colitis, Crohn's disease and colon carcinoma. In the first two conditions, a marked oxidative stress is consistently present, while in the third one, levels of reactive oxygen species tend to be significantly lower than in the surrounding normal tissue. Lipid-derived compounds such as the aldehyde 4-hydroxynonenal (HNE) or cholesterol oxidation products (oxysterols) were shown able to induce expression and synthesis of TGFbeta1, an event which can be detrimental or beneficial, essentially depending on its actual intensity. Understanding how specific dietary lipids may influence the complex molecular signaling underlying this cytokine expression, may provide new indications for therapeutic and preventive strategies in inflammatory bowel diseases and colon carcinoma.

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