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Adesegun SA, Fajana A, Orabueze CI, et al. Evaluation of Antioxidant Properties of Phaulopsis fascisepala C.B.Cl. (Acanthaceae). Evid Based Complement Alternat Med. 2007;6(2):227-31doi: 10.1093/ecam/nem098.
Adesegun, S. A., Fajana, A., Orabueze, C. I., & Coker, H. A. (2009). Evaluation of Antioxidant Properties of Phaulopsis fascisepala C.B.Cl. (Acanthaceae). Evidence-based complementary and alternative medicine : eCAM, 6(2), 227-31. https://doi.org/10.1093/ecam/nem098
Adesegun, S A, et al. "Evaluation of Antioxidant Properties of Phaulopsis fascisepala C.B.Cl. (Acanthaceae)." Evidence-based complementary and alternative medicine : eCAM vol. 6,2 (2009): 227-31. doi: https://doi.org/10.1093/ecam/nem098
Adesegun SA, Fajana A, Orabueze CI, Coker HA. Evaluation of Antioxidant Properties of Phaulopsis fascisepala C.B.Cl. (Acanthaceae). Evid Based Complement Alternat Med. 2009 Jun;6(2):227-31. doi: 10.1093/ecam/nem098. Epub 2007 Oct 04. PMID: 18955238; PMCID: PMC2686633.
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Evid Based Complement Alternat Med. 2009 Jun;6(2):227-31. doi: 10.1093/ecam/nem098. Epub 2007 Oct 04.

Evaluation of Antioxidant Properties of Phaulopsis fascisepala C.B.Cl. (Acanthaceae).

Evidence-based complementary and alternative medicine : eCAM

S A Adesegun, A Fajana, C I Orabueze, H A B Coker

Affiliations

  1. Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, PMB 12003, Lagos, Nigeria. [email protected].

PMID: 18955238 PMCID: PMC2686633 DOI: 10.1093/ecam/nem098

Abstract

The antioxidant activities of crude extract of Phaulopsis fascisepala leaf were evaluated and compared with alpha-tocopherol and BHT as synthetic antioxidants and ascorbic acid as natural-based antioxidant. In vitro, we studied its antioxidative activities, radical-scavenging effects, Fe(2+)-chelating ability and reducing power. The total phenolic content was determined and expressed in gallic acid equivalent. The extract showed variable activities in all of these in vitro tests. The antioxidant effect of P. fascisepala was strongly dose dependent, increased with increasing leaf extract dose and then leveled off with further increase in extract dose. Compared to other antioxidants used in the study, alpha-Tocopherol, ascorbic acid and BHT, P. fascisepala leaf extract showed less scavenging effect on alpha,alpha,-diphenyl-beta-picrylhydrazyl (DPPH) radical and less reducing power on Fe(3+)/ferricyanide complex but better Fe(2+)-chelating ability. These results revealed the in vitro antioxidant activity of P. fascisepala. Further investigations are necessary to verify these activities in vivo.

Keywords: iron chelating power; phenolic content; radical scavenging; reducing power

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