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Rostedt A, Saders LL, Edards LJ, et al. Predictive value of single-fiber electromyography in the extensor digitorum communis muscle of patients with ocular myasthenia gravis: a retrospective study. J Clin Neuromuscul Dis. 2000;2(1):6-9doi: 10.1097/00131402-200009000-00003.
Rostedt, A., Saders, L. L., Edards, L. J., Massey, J. M., Sanders, D. B., & Stålberg, E. V. (2000). Predictive value of single-fiber electromyography in the extensor digitorum communis muscle of patients with ocular myasthenia gravis: a retrospective study. Journal of clinical neuromuscular disease, 2(1), 6-9. https://doi.org/10.1097/00131402-200009000-00003
Rostedt, A, et al. "Predictive value of single-fiber electromyography in the extensor digitorum communis muscle of patients with ocular myasthenia gravis: a retrospective study." Journal of clinical neuromuscular disease vol. 2,1 (2000): 6-9. doi: https://doi.org/10.1097/00131402-200009000-00003
Rostedt A, Saders LL, Edards LJ, Massey JM, Sanders DB, Stålberg EV. Predictive value of single-fiber electromyography in the extensor digitorum communis muscle of patients with ocular myasthenia gravis: a retrospective study. J Clin Neuromuscul Dis. 2000 Sep;2(1):6-9. doi: 10.1097/00131402-200009000-00003. PMID: 19078595.
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J Clin Neuromuscul Dis. 2000 Sep;2(1):6-9. doi: 10.1097/00131402-200009000-00003.

Predictive value of single-fiber electromyography in the extensor digitorum communis muscle of patients with ocular myasthenia gravis: a retrospective study.

Journal of clinical neuromuscular disease

A Rostedt, L L Saders, L J Edards, J M Massey, D B Sanders, E V Stålberg

Affiliations

  1. From the *Department of Clinical Neurophysiology, University Hospital, Uppsala, Sweden: and the daggerDepartment of Medicine, Duke University Medical Center Drham, North Carolina USA.

PMID: 19078595 DOI: 10.1097/00131402-200009000-00003

Abstract

PURPOSE: To determine if the jitter in the extensor digitorum communis (EDC) muscle in patients with purely ocular myasthenia gravis (OMG) predicts the subsequent development of generalized myasthenic weakness-Methods: Included in this retrospective study were patients who initially had purely ocular manifestations and had been followed for at least 2 years after onset of myasthenic symptoms. The group consisted of 50 patients with purely ocular weakness, 26 of whom later generalized. All underwent single-fiber electromyography (SFEMG) studies in the EDC muscle at the initial examination

RESULTS: : Statistical analysis did not demonstrate that the amount of jitter in the EDC muscle predicted the development of generalized myasthenia gravis (GMG). Also, there was no threshold jitter value that predicted generalized weakness.

CONCLUSIONS: : SFEMG measurement of jitter in the EDC muscle demonstrates abnormal neuromuscular transmission in many patients with OMG but is not useful in predicting generalization in these patients.

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