Br J Pharmacol Chemother. 1961 Apr;16(2):180-7. doi: 10.1111/j.1476-5381.1961.tb00311.x.

Salicylate and liver glutathione.

British journal of pharmacology and chemotherapy

D H Sproull

PMID: 19108147 PMCID: PMC1481952 DOI: 10.1111/j.1476-5381.1961.tb00311.x

Abstract

The effects of sodium salicylate, benzoate, gentisate, m- and p-hydroxybenzoates, antipyrine, and 2:4-dinitrophenol on the reduced glutathione concentration of rat liver were determined. An increase in concentration in the male, but not in the female, rats was found after salicylate, benzoate and gentisate; after antipyrine, a comparable increase occurred in the females only. There is a relation, in these compounds, between capacity to increase the concentration of reduced glutathione in the rat liver in one sex and therapeutic activity in rheumatic fever.

References

1. Biochem J. 1957 Jun;66(2):222-7 - PubMed
2. Biochem J. 1951 Dec;50(2):154-62 - PubMed
3. J Pharmacol Exp Ther. 1950 Jan;98(1):45-8 - PubMed
4. Br J Pharmacol Chemother. 1958 Dec;13(4):419-23 - PubMed
5. Biochem J. 1955 Aug;60(4):696-702 - PubMed
6. J Pharm Pharmacol. 1952 Sep;4(9):624-30 - PubMed
7. J Clin Invest. 1958 Aug;37(8):1131-43 - PubMed
8. J Clin Invest. 1958 Aug;37(8):1144-52 - PubMed
9. Ann Rheum Dis. 1954 Mar;13(1):60-2 - PubMed
10. Endocrinology. 1955 May;56(5):560-6 - PubMed
11. Biochem J. 1942 Dec;36(10-12):706-28 - PubMed

Publication Types

• Journal Article