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Spencer PS, West GB. Sensitivity of the hyperthyroid and hypothyroid mouse to histamine and 5-hydroxytryptamine. Br J Pharmacol Chemother. 1961;17(1):137-43doi: 10.1111/j.1476-5381.1961.tb01114.x.
Spencer, P. S., & West, G. B. (1961). Sensitivity of the hyperthyroid and hypothyroid mouse to histamine and 5-hydroxytryptamine. British journal of pharmacology and chemotherapy, 17(1), 137-43. https://doi.org/10.1111/j.1476-5381.1961.tb01114.x
Spencer, P S, and West, G B. "Sensitivity of the hyperthyroid and hypothyroid mouse to histamine and 5-hydroxytryptamine." British journal of pharmacology and chemotherapy vol. 17,1 (1961): 137-43. doi: https://doi.org/10.1111/j.1476-5381.1961.tb01114.x
Spencer PS, West GB. Sensitivity of the hyperthyroid and hypothyroid mouse to histamine and 5-hydroxytryptamine. Br J Pharmacol Chemother. 1961 Aug;17(1):137-43. doi: 10.1111/j.1476-5381.1961.tb01114.x. PMID: 19108156; PMCID: PMC1482074.
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Br J Pharmacol Chemother. 1961 Aug;17(1):137-43. doi: 10.1111/j.1476-5381.1961.tb01114.x.

Sensitivity of the hyperthyroid and hypothyroid mouse to histamine and 5-hydroxytryptamine.

British journal of pharmacology and chemotherapy

P S Spencer, G B West

PMID: 19108156 PMCID: PMC1482074 DOI: 10.1111/j.1476-5381.1961.tb01114.x

Abstract

Injections of thyroxine sodium increased the sensitivity of mice to histamine, the maximal effect occurring after 6 days. The sensitivity to 5-hydroxytryptamine was increased to a lesser extent. Hydrocortisone antagonized this effect of thyroxine, whereas anti-thyroid drugs alone decreased the sensitivity to histamine. Treatment with thyroxine also raised the metabolic rate, the peak again being reached after 6 days. As treatment was continued beyond 6 days, the adrenal gland enlarged and its secretion probably accounted for the decline in the histamine sensitivity.

References

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