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Arora RB, Sivappa DS. Ectopic ventricular rhythms and myocardial infarction in the domestic pig and their response to nialamide, a monoamine oxidase inhibitor. Br J Pharmacol Chemother. 1962;19(3):394-404doi: 10.1111/j.1476-5381.1962.tb01444.x.
Arora, R. B., & Sivappa, D. S. (1962). Ectopic ventricular rhythms and myocardial infarction in the domestic pig and their response to nialamide, a monoamine oxidase inhibitor. British journal of pharmacology and chemotherapy, 19(3), 394-404. https://doi.org/10.1111/j.1476-5381.1962.tb01444.x
Arora, R B, and Sivappa, D S. "Ectopic ventricular rhythms and myocardial infarction in the domestic pig and their response to nialamide, a monoamine oxidase inhibitor." British journal of pharmacology and chemotherapy vol. 19,3 (1962): 394-404. doi: https://doi.org/10.1111/j.1476-5381.1962.tb01444.x
Arora RB, Sivappa DS. Ectopic ventricular rhythms and myocardial infarction in the domestic pig and their response to nialamide, a monoamine oxidase inhibitor. Br J Pharmacol Chemother. 1962 Dec;19(3):394-404. doi: 10.1111/j.1476-5381.1962.tb01444.x. PMID: 19108169; PMCID: PMC1482219.
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Br J Pharmacol Chemother. 1962 Dec;19(3):394-404. doi: 10.1111/j.1476-5381.1962.tb01444.x.

Ectopic ventricular rhythms and myocardial infarction in the domestic pig and their response to nialamide, a monoamine oxidase inhibitor.

British journal of pharmacology and chemotherapy

R B Arora, D S Sivappa

PMID: 19108169 PMCID: PMC1482219 DOI: 10.1111/j.1476-5381.1962.tb01444.x

Abstract

The development in Indian domestic pigs of ectopic ventricular rhythms and a low-frequency tachycardia after the two-stage ligature of the anterior descending branch of the left coronary artery is described. When the ligature was tied 26+/-3 mm from the left auricular margin, the change in rhythm developed after 2 to 2.5 hr, reached a maximum after 6 hr and persisted up to 28 hr. The histopathological character of the resultant acute myocardial infarction is presented. In all, 52 pigs were used. Pretreatment of 9 pigs, with 3 as controls, with a monoamine oxidase inhibitor, nialamide, 20 mg/kg daily for 2 to 4 days, suppressed the development of experimental ventricular arrhythmia and favourably influenced the ischaemic myocardium by reducing the oedema and the formation of microthrombi. A possible mode of action involving monoamine oxidase inhibition is suggested.

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