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Br J Pharmacol Chemother. 1962 Dec;19(3):442-50. doi: 10.1111/j.1476-5381.1962.tb01448.x.

Influence of metals on the activity of a bradykinin-destroying enzyme kininase.

British journal of pharmacology and chemotherapy

P N Aarsen, A Kemp

PMID: 19108170 PMCID: PMC1482212 DOI: 10.1111/j.1476-5381.1962.tb01448.x

Abstract

Kininase prepared from guinea-pig serum was inhibited by cysteine at pH 7.4 to 7.6. A similar effect was found with edetic acid. The enzyme blocked by edetic acid was reactivated immediately by addition of Mn(++), Co(++) and Zn(++). These findings indicate that kininase is a metal-activated enzyme.

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