Display options
Cite
St-Germain G, Laverdière M, Pelletier R, et al. Epidemiology and antifungal susceptibility of bloodstream Candida isolates in Quebec: Report on 453 cases between 2003 and 2005. Can J Infect Dis Med Microbiol. 2008;19(1):55-62doi: 10.1155/2008/634046.
St-Germain, G., Laverdière, M., Pelletier, R., René, P., Bourgault, A. M., Lemieux, C., & Libman, M. (2008). Epidemiology and antifungal susceptibility of bloodstream Candida isolates in Quebec: Report on 453 cases between 2003 and 2005. The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 19(1), 55-62. https://doi.org/10.1155/2008/634046
St-Germain, Guy, et al. "Epidemiology and antifungal susceptibility of bloodstream Candida isolates in Quebec: Report on 453 cases between 2003 and 2005." The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale vol. 19,1 (2008): 55-62. doi: https://doi.org/10.1155/2008/634046
St-Germain G, Laverdière M, Pelletier R, René P, Bourgault AM, Lemieux C, Libman M. Epidemiology and antifungal susceptibility of bloodstream Candida isolates in Quebec: Report on 453 cases between 2003 and 2005. Can J Infect Dis Med Microbiol. 2008 Jan;19(1):55-62. doi: 10.1155/2008/634046. PMID: 19145263; PMCID: PMC2610277.
Copy Download .nbib Format: NLM
Share it on

Can J Infect Dis Med Microbiol. 2008 Jan;19(1):55-62. doi: 10.1155/2008/634046.

Epidemiology and antifungal susceptibility of bloodstream Candida isolates in Quebec: Report on 453 cases between 2003 and 2005.

The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

Guy St-Germain, Michel Laverdière, René Pelletier, Pierre René, Anne-Marie Bourgault, Claude Lemieux, Michael Libman

Affiliations

  1. Laboratoire de santé publique/Institut national de santé publique du Québec, Québec City, Québec.

PMID: 19145263 PMCID: PMC2610277 DOI: 10.1155/2008/634046

Abstract

BACKGROUND: Between May 2003 and April 2005, a population-based surveillance of Candida bloodstream infections was conducted in Quebec. A total of 453 episodes of candidemia (464 yeast isolates) from 54 participating hospitals were studied.

RESULTS: The annual incidence rate was three per 100,000 population. Global hospital mortality was 38%. The most common predisposing factors were the presence of an intravascular catheter (80%), use of antibacterial therapy (67%), stay in an intensive care unit (49%), use of parenteral nutrition (32%) and intra-abdominal surgery (31%). Fluconazole alone or in association with other antifungals was used for treatment in over 80% of cases. Candida albicans comprised 62% of isolates, followed by Candida glabrata (17%), Candida parapsilosis (9%), Candida tropicalis (5%), Candida lusitaniae (3%) and Candida krusei (3%). Of the 288 C albicans isolates, seven (2%) were resistant to flucytosine, one to fluconazole and none to itraconazole or voriconazole. Of the 75 non-C albicans species isolates with reduced susceptibility to fluconazole (minimum inhibitory concentration [MIC] 16 mug/mL or greater), none were susceptible to itraconazole (MIC 0.12 mg/L or lower), whereas 71 (95%) were susceptible to voriconazole (MIC 1 mug/mL or lower). However, only five of 12 (42%) fluconazole-resistant isolates were susceptible to voriconazole. Posaconazole, ravuconazole and caspofungin displayed a broad spectrum of activity against these isolates, with MICs of 1 mg/L or lower in 56%, 92% and 100% of isolates, respectively. Overall, a correlation (r(2)>0.87) was observed among increasing fluconazole MICs and the geometric mean MICs of itraconazole, voriconazole, posaconazole and ravuconazole.

CONCLUSIONS: These surveillance results when compared with those of the 1993 to 1995 survey confirm little variation in the distribution of species causing invasive Candida infection over a 10-year period in Quebec, as well as the continuous excellent overall in vitro activity of fluconazole.

Keywords: Antifungal resistance; Candidemia; Surveillance

References

  1. Antimicrob Agents Chemother. 1995 Apr;39(4):906-9 - PubMed
  2. J Clin Microbiol. 2006 May;44(5):1782-7 - PubMed
  3. J Clin Microbiol. 2001 Jan;39(1):323-7 - PubMed
  4. Clin Infect Dis. 2006 Apr 1;42(7):938-44 - PubMed
  5. J Antimicrob Chemother. 2005 Feb;55(2):194-9 - PubMed
  6. CMAJ. 1999 Feb 23;160(4):493-9 - PubMed
  7. J Infect Dis. 1993 May;167(5):1247-51 - PubMed
  8. Antimicrob Agents Chemother. 1998 Jan;42(1):129-34 - PubMed
  9. J Clin Microbiol. 2007 Jan;45(1):70-5 - PubMed
  10. J Clin Microbiol. 2001 Mar;39(3):949-53 - PubMed
  11. Clin Microbiol Infect. 2004 Mar;10 Suppl 1:11-23 - PubMed
  12. J Clin Microbiol. 2002 Sep;40(9):3489-92 - PubMed
  13. J Clin Microbiol. 2007 Jun;45(6):1735-45 - PubMed
  14. Antimicrob Agents Chemother. 2000 Aug;44(8):2081-5 - PubMed
  15. Clin Microbiol Rev. 1999 Jan;12(1):80-96 - PubMed
  16. J Clin Microbiol. 2006 Jun;44(6):1977-81 - PubMed
  17. Emerg Infect Dis. 2003 Aug;9(8):985-90 - PubMed
  18. J Clin Microbiol. 1998 Dec;36(12):3455-9 - PubMed
  19. J Clin Microbiol. 2004 Jul;42(7):3117-9 - PubMed
  20. J Clin Microbiol. 2006 Mar;44(3):760-3 - PubMed
  21. J Clin Microbiol. 2005 Aug;43(8):3807-10 - PubMed
  22. J Antimicrob Chemother. 2005 Sep;56(3):532-7 - PubMed
  23. Ann Intern Med. 2005 Dec 20;143(12):857-69 - PubMed
  24. Clin Infect Dis. 1999 Aug;29(2):239-44 - PubMed
  25. J Clin Microbiol. 2004 Apr;42(4):1519-27 - PubMed
  26. Infect Control Hosp Epidemiol. 2005 Jun;26(6):540-7 - PubMed
  27. J Clin Microbiol. 2005 Apr;43(4):1829-35 - PubMed
  28. J Clin Microbiol. 2002 Apr;40(4):1298-302 - PubMed
  29. Diagn Microbiol Infect Dis. 1997 Sep;29(1):5-9 - PubMed
  30. Clin Infect Dis. 1999 Nov;29(5):1164-70 - PubMed
  31. Clin Infect Dis. 2005 Nov 1;41(9):1232-9 - PubMed
  32. Clin Microbiol Rev. 2001 Oct;14(4):643-58, table of contents - PubMed
  33. Antimicrob Agents Chemother. 2006 Apr;50(4):1287-92 - PubMed
  34. J Clin Microbiol. 2005 Sep;43(9):4535-40 - PubMed
  35. Mycoses. 2002 Jun;45(5-6):141-5 - PubMed
  36. Medicine (Baltimore). 1993 May;72(3):143-50 - PubMed
  37. Rev Iberoam Micol. 2000 Sep;17(3):73-81 - PubMed
  38. J Clin Microbiol. 2004 Aug;42(8):3475-82 - PubMed
  39. J Clin Microbiol. 2006 Aug;44(8):2816-23 - PubMed

Publication Types