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Drug Discov Today. 2010 Jan;15(1):23-32. doi: 10.1016/j.drudis.2008.12.006. Epub 2009 Jan 14.

Molecular fields in drug discovery: getting old or reaching maturity?.

Drug discovery today

Simon Cross, Gabriele Cruciani

Affiliations

  1. Molecular Discovery Limited, 215 Marsh Road, Pinner, Middlesex, London HA5 5NE, United Kingdom. [email protected]

PMID: 19150413 DOI: 10.1016/j.drudis.2008.12.006

Abstract

With GRID first published 23 years ago, and CoMFA 20 years ago, the two most widely known methods that apply molecular fields to drug discovery are now into their third decade. Are molecular-field-based methods still applicable to modern drug discovery? Are they old and outdated? Or are they maturing into their full potential?

Copyright 2008 Elsevier Ltd. All rights reserved.

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