Drug Discov Today. 2010 Jan;15(1):23-32. doi: 10.1016/j.drudis.2008.12.006. Epub 2009 Jan 14.
Drug discovery today
Simon Cross, Gabriele Cruciani
PMID: 19150413 DOI: 10.1016/j.drudis.2008.12.006
With GRID first published 23 years ago, and CoMFA 20 years ago, the two most widely known methods that apply molecular fields to drug discovery are now into their third decade. Are molecular-field-based methods still applicable to modern drug discovery? Are they old and outdated? Or are they maturing into their full potential?
Copyright 2008 Elsevier Ltd. All rights reserved.