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Voogt JL, Reseh G, Turkington S. Arcuate Nucleus and Preoptic Area Involvement in Beta-Endorphin-lnduced Release of Prolactin in Conscious Ovariectomized Ratsdagger. J Neuroendocrinol. 1989;1(6):449-53doi: 10.1111/j.1365-2826.1989.tb00146.x.
Voogt, J. L., Reseh, G., & Turkington, S. (1989). Arcuate Nucleus and Preoptic Area Involvement in Beta-Endorphin-lnduced Release of Prolactin in Conscious Ovariectomized Ratsdagger. Journal of neuroendocrinology, 1(6), 449-53. https://doi.org/10.1111/j.1365-2826.1989.tb00146.x
Voogt, J L, et al. "Arcuate Nucleus and Preoptic Area Involvement in Beta-Endorphin-lnduced Release of Prolactin in Conscious Ovariectomized Ratsdagger." Journal of neuroendocrinology vol. 1,6 (1989): 449-53. doi: https://doi.org/10.1111/j.1365-2826.1989.tb00146.x
Voogt JL, Reseh G, Turkington S. Arcuate Nucleus and Preoptic Area Involvement in Beta-Endorphin-lnduced Release of Prolactin in Conscious Ovariectomized Ratsdagger. J Neuroendocrinol. 1989 Dec 01;1(6):449-53. doi: 10.1111/j.1365-2826.1989.tb00146.x. PMID: 19210416.
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J Neuroendocrinol. 1989 Dec 01;1(6):449-53. doi: 10.1111/j.1365-2826.1989.tb00146.x.

Arcuate Nucleus and Preoptic Area Involvement in Beta-Endorphin-lnduced Release of Prolactin in Conscious Ovariectomized Ratsdagger.

Journal of neuroendocrinology

J L Voogt, G Reseh, S Turkington

Affiliations

  1. Department of Physiology, Kansas University Medical Center, Kansas City, Kansas 66103, USA.

PMID: 19210416 DOI: 10.1111/j.1365-2826.1989.tb00146.x

Abstract

Abstract The ability of ss-endorphin (ss-END) to release prolactin and the ability of naloxone to block prolactin's release when delivered to specific hypothalamic areas via push-pull perfusion was studied in unrestrained, conscious, Ovariectomized rats. Perfusion of either the arcuate nucleus or the preoptic area with ss-END for 15 to 30 min caused a large, brief increase in plasma prolactin levels. Perfusion for a longer time period (120 min) resulted in peak prolactin levels at 60 min, with a return to baseline by 120 min, suggesting that ss-END primarily acts to induce a sequence of events that culminates in prolactin release, but other factors are needed to maintain this release over long periods of time. Perfusion of the arcuate nucleus for two 15-min periods 90 min apart resulted in two surges of prolactin. When naloxone, the opiate receptor antagonist, was added to the perfusate, ss-END was not capable of stimulating prolactin release. These results provide a model to answer whether endogenous ss-END has a role in the neuroendocrine regulation of prolactin surges and what the location is of the opiate neurons involved in this neuronal pathway.

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