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Goascogne C, Gouézou M, Robel P, et al. The cholesterol side-chain cleavage complex in human brain white matter. J Neuroendocrinol. 1989;1(3):153-6doi: 10.1111/j.1365-2826.1989.tb00095.x.
Goascogne, C., Gouézou, M., Robel, P., Defaye, G., Chambaz, E., Waterman, M. R., & Baulieu, E. E. (1989). The cholesterol side-chain cleavage complex in human brain white matter. Journal of neuroendocrinology, 1(3), 153-6. https://doi.org/10.1111/j.1365-2826.1989.tb00095.x
Goascogne, C, et al. "The cholesterol side-chain cleavage complex in human brain white matter." Journal of neuroendocrinology vol. 1,3 (1989): 153-6. doi: https://doi.org/10.1111/j.1365-2826.1989.tb00095.x
Goascogne C, Gouézou M, Robel P, Defaye G, Chambaz E, Waterman MR, Baulieu EE. The cholesterol side-chain cleavage complex in human brain white matter. J Neuroendocrinol. 1989 Jun 01;1(3):153-6. doi: 10.1111/j.1365-2826.1989.tb00095.x. PMID: 19210447.
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J Neuroendocrinol. 1989 Jun 01;1(3):153-6. doi: 10.1111/j.1365-2826.1989.tb00095.x.

The cholesterol side-chain cleavage complex in human brain white matter.

Journal of neuroendocrinology

C Goascogne, M Gouézou, P Robel, G Defaye, E Chambaz, M R Waterman, E E Baulieu

Affiliations

  1. INSERM U 33, Communications Hormonales and Faculté de Médicine, Université Paris-Sud, F-94275 Bicêtre Cedex, France.

PMID: 19210447 DOI: 10.1111/j.1365-2826.1989.tb00095.x

Abstract

Abstract Specific antibodies obtained in rabbits after injection of bovine cholesterol side-chain cleavage enzymes cytochrome P-450scc, adrenodoxin and adrenodoxin-reductase were used for immunohistochemical studies in human brain. The three enzymes were co-localized in the white matter of the cerebellum. This observation strongly suggests the existence of steroidogenic activity in human oligodendrocytes, as previously reported in the rat, and suggests that the concept of 'neurosteroids' can be applied to Delta5-3ss-hydroxysteroid metabolites of cholesterol that accumulate in human brain.

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