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Mansour SZ, El-Kabany H. Effects of Fructus Piperis Longi extract on fibrotic liver of gamma-irradiated rats. Chin Med. 2009;4:2doi: 10.1186/1749-8546-4-2.
Mansour, S. Z., & El-Kabany, H. (2009). Effects of Fructus Piperis Longi extract on fibrotic liver of gamma-irradiated rats. Chinese medicine, 42. https://doi.org/10.1186/1749-8546-4-2
Mansour, Somaya Zakaria, and El-Kabany, Hanan. "Effects of Fructus Piperis Longi extract on fibrotic liver of gamma-irradiated rats." Chinese medicine vol. 4 (2009): 2. doi: https://doi.org/10.1186/1749-8546-4-2
Mansour SZ, El-Kabany H. Effects of Fructus Piperis Longi extract on fibrotic liver of gamma-irradiated rats. Chin Med. 2009 Jan 30;4:2. doi: 10.1186/1749-8546-4-2. PMID: 19183455; PMCID: PMC2657146.
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Chin Med. 2009 Jan 30;4:2. doi: 10.1186/1749-8546-4-2.

Effects of Fructus Piperis Longi extract on fibrotic liver of gamma-irradiated rats.

Chinese medicine

Somaya Zakaria Mansour, Hanan El-Kabany

Affiliations

  1. Radiation Biology Department, National Centre for Radiation Research and Technology, Atomic Authority, Cairo, Egypt. [email protected]

PMID: 19183455 PMCID: PMC2657146 DOI: 10.1186/1749-8546-4-2

Abstract

BACKGROUND: A major biomarker for liver fibrosis is transglutaminase which catalyzes cross-linking of epsilon-amines and alpha-glutamyl residues among amino acids leading to fibrosis. Fructus Piperis Longi is a common herb used in Chinese medicine. The present study evaluates the role of the ethanol extract of Fructus Piperis Longi in the modulation of liver function in liver fibrosis.

METHODS: Plf extract (50 mg/kg) was force-fed to rats every other day 7 days before administration of thioacetamide and/or gamma irradiation. Thioacetamid 200 mg/kg was intraperitoneally administered to rats twice per week for four weeks. Rats were gamma irradiated (2 Gy/week up to a total dose of 8 Gy). Administration of Plf ext was extended during thioacetamid and/or irradiation treatment. Animals were sacrificed. Biochemical parameters in homogenised liver were tested.

RESULTS: A significant increase in transglutaminase activity and collagen content was recorded in the liver of thioacetamid-treated and/or irradiated rats. Significant increases in lipid peroxides, lipid hydroperoxides and conjugated dienes associated to significant decreases of reduced glutathione content, superoxide dismutase and catalase activities were also recorded. Administration of Plf ext treatment reduced the severity of liver fibrosis and oxidative damage which was substantiated by amelioration of liver function detected by a decrease in serum aspartate aminotransaminase, alanine aminotransferase, alkaline phosphatase, gamma glutamyltransferase activities and bilirubin (total, direct and indirect) content.

CONCLUSION: Treatment of the ethanolic extract of Fructus Piperis Longi ameliorated the increase of the activity of tTG enzyme and enhanced antioxidant activities in fibrotic liver.

References

  1. Br J Cancer. 1999 May;80(5-6):629-38 - PubMed
  2. Cancer Lett. 1989 Jun;45(3):195-202 - PubMed
  3. Mol Pharmacol. 1972 May;8(3):318-26 - PubMed
  4. Food Chem Toxicol. 1986 Dec;24(12):1321-4 - PubMed
  5. Biometals. 1998 Apr;11(2):153-7 - PubMed
  6. J Biol Chem. 1991 Aug 15;266(23):15308-17 - PubMed
  7. Indian J Exp Biol. 1999 Mar;37(3):262-8 - PubMed
  8. Free Radic Biol Med. 1995 Nov;19(5):659-63 - PubMed
  9. Clin Chem. 1983 Feb;29(2):297-301 - PubMed
  10. Am J Clin Pathol. 1957 Jul;28(1):56-63 - PubMed
  11. Anal Biochem. 1972 Jun;47(2):389-94 - PubMed
  12. Clin Chim Acta. 1979 Mar 15;92(3):337-42 - PubMed
  13. Georgian Med News. 2005 Jul-Aug;(124-125):75-9 - PubMed
  14. Toxicology. 2008 Apr 18;246(2-3):148-57 - PubMed
  15. J Neurochem. 2000 Nov;75(5):1951-61 - PubMed
  16. Arch Toxicol. 2007 Jan;81(1):45-55 - PubMed
  17. Dig Liver Dis. 2004 Apr;36(4):231-42 - PubMed
  18. Science. 1945 Jul 20;102(2638):68 - PubMed
  19. J Dent Res. 1994 May;73(5):1043-9 - PubMed
  20. J Clin Invest. 1998 Aug 1;102(3):538-49 - PubMed
  21. Life Sci. 2005 Jul 1;77(7):780-94 - PubMed
  22. J Pharmacol Exp Ther. 1977 Feb;200(2):439-48 - PubMed
  23. Clin Chem Lab Med. 2003 Jul;41(7):926-33 - PubMed
  24. Am J Obstet Gynecol. 1979 Oct 1;135(3):372-6 - PubMed
  25. FASEB J. 1991 Dec;5(15):3071-7 - PubMed
  26. Br J Cancer. 1997;75(4):487-92 - PubMed
  27. Cell Mol Life Sci. 2004 Jan;61(1):83-96 - PubMed
  28. J Toxicol Sci. 1993 Nov;18(4):239-44 - PubMed
  29. Ukr Biokhim Zh (1999). 2001 Jan-Feb;73(1):73-7 - PubMed
  30. Phytomedicine. 2006 Feb;13(3):196-8 - PubMed
  31. Phytother Res. 2002 Mar;16 Suppl 1:S28-32 - PubMed
  32. J Clin Invest. 1997 Jun 15;99(12):2950-60 - PubMed
  33. Methods Enzymol. 1984;105:331-7 - PubMed
  34. Toxicology. 2000 Nov 23;154(1-3):21-9 - PubMed
  35. Am J Physiol. 1997 Feb;272(2 Pt 1):G281-8 - PubMed
  36. Drug Metab Dispos. 1978 Jul-Aug;6(4):379-88 - PubMed
  37. J Lab Clin Med. 1963 May;61:882-8 - PubMed
  38. Biochem J. 2002 Dec 15;368(Pt 3):695-704 - PubMed
  39. Arch Biochem Biophys. 1961 May;93:440-7 - PubMed
  40. J Agric Food Chem. 2003 Mar 26;51(7):2083-8 - PubMed
  41. Phytother Res. 2002 Aug;16(5):461-6 - PubMed
  42. Clin Chem. 1976 Dec;22(12):2051-5 - PubMed
  43. Anal Biochem. 2000 Oct 1;285(1):16-20 - PubMed
  44. J Pharmacol Exp Ther. 2001 Jul;298(1):103-9 - PubMed
  45. Thromb Haemost. 1994 Apr;71(4):402-15 - PubMed
  46. J Hepatol. 1999 Jul;31(1):27-38 - PubMed
  47. J Am Soc Nephrol. 2003 Aug;14(8):2052-62 - PubMed
  48. Anal Biochem. 1992 May 1;202(2):384-9 - PubMed

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