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Brooks PJ, Lund PK, Stumpf WE, et al. Oxytocin Messenger Ribonucleic Acid Levels in the Medial Preoptic Area are Increased During Lactation. J Neuroendocrinol. 1990;2(5):621-6doi: 10.1111/j.1365-2826.1990.tb00456.x.
Brooks, P. J., Lund, P. K., Stumpf, W. E., & Pedersen, C. A. (1990). Oxytocin Messenger Ribonucleic Acid Levels in the Medial Preoptic Area are Increased During Lactation. Journal of neuroendocrinology, 2(5), 621-6. https://doi.org/10.1111/j.1365-2826.1990.tb00456.x
Brooks, P J, et al. "Oxytocin Messenger Ribonucleic Acid Levels in the Medial Preoptic Area are Increased During Lactation." Journal of neuroendocrinology vol. 2,5 (1990): 621-6. doi: https://doi.org/10.1111/j.1365-2826.1990.tb00456.x
Brooks PJ, Lund PK, Stumpf WE, Pedersen CA. Oxytocin Messenger Ribonucleic Acid Levels in the Medial Preoptic Area are Increased During Lactation. J Neuroendocrinol. 1990 Oct 01;2(5):621-6. doi: 10.1111/j.1365-2826.1990.tb00456.x. PMID: 19215397.
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J Neuroendocrinol. 1990 Oct 01;2(5):621-6. doi: 10.1111/j.1365-2826.1990.tb00456.x.

Oxytocin Messenger Ribonucleic Acid Levels in the Medial Preoptic Area are Increased During Lactation.

Journal of neuroendocrinology

P J Brooks, P K Lund, W E Stumpf, C A Pedersen

Affiliations

  1. Curriculum in Neurobiology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599-7250, USA.

PMID: 19215397 DOI: 10.1111/j.1365-2826.1990.tb00456.x

Abstract

Abstract The peptide hormone oxytocin has an important role in parturition, lactation and maternal behavior. The present study employed in situ hybridization histochemistry to determine whether oxytocin messenger ribonucleic acid (mRNA) levels in cells in the medial preoptic area, a brain area known to control maternal behavior, change during pregnancy and lactation in the rat. Female rats were perfused on either Day 18 or 22 of pregnancy or Day 5 of lactation. Ovariectomized female rats were included as an additional control group. Cells expressing oxytocin mRNA were detected by in situ hybridization using an [(125) l]-labeled 38 base synthetic oligodeoxynucleotide probe complementary to the C-terminal coding region of the preprooxytocin. Relative differences in oxytocin mRNA levels were determined by silver grain counting of labeled cells. A group of oxytocin neurons in the dorsal medial preoptic area, called the lateral subcommissural nucleus, showed elevated oxytocin mRNA levels in lactating animals relative to ail other groups. Oxytocin mRNA levels in the neurons of the periventricular nucleus of the preoptic area did not change across pregnancy and lactation. This result extends the findings of others showing elevated oxytocin mRNA levels in magnocellular nuclei of lactating animals. The results are discussed in terms of the possible role of oxytocin cells in the medial preoptic area in the expression of maternal behavior.

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