Display options
Cite
van Wissen M, Keller TT, Ronkes B, et al. Influenza infection and risk of acute pulmonary embolism. Thromb J. 2007;5:16doi: 10.1186/1477-9560-5-16.
van Wissen, M., Keller, T. T., Ronkes, B., Gerdes, V. E., Zaaijer, H. L., van Gorp, E. C., Brandjes, D. P., Levi, M., & Büller, H. R. (2007). Influenza infection and risk of acute pulmonary embolism. Thrombosis journal, 516. https://doi.org/10.1186/1477-9560-5-16
van Wissen, Matthijs, et al. "Influenza infection and risk of acute pulmonary embolism." Thrombosis journal vol. 5 (2007): 16. doi: https://doi.org/10.1186/1477-9560-5-16
van Wissen M, Keller TT, Ronkes B, Gerdes VE, Zaaijer HL, van Gorp EC, Brandjes DP, Levi M, Büller HR. Influenza infection and risk of acute pulmonary embolism. Thromb J. 2007 Oct 16;5:16. doi: 10.1186/1477-9560-5-16. PMID: 17939867; PMCID: PMC2104525.
Copy Download .nbib Format: NLM
Share it on

Thromb J. 2007 Oct 16;5:16. doi: 10.1186/1477-9560-5-16.

Influenza infection and risk of acute pulmonary embolism.

Thrombosis journal

Matthijs van Wissen, Tymen T Keller, Brechje Ronkes, Victor Ea Gerdes, Hans L Zaaijer, Eric Cm van Gorp, Dees Pm Brandjes, Marcel Levi, Harry R Büller

Affiliations

  1. Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands. [email protected].

PMID: 17939867 PMCID: PMC2104525 DOI: 10.1186/1477-9560-5-16

Abstract

BACKGROUND: Influenza infections have been associated with procoagulant changes. Whether influenza infections lead to an increased risk of pulmonary embolism remains to be established.

METHODS: We conducted a nested case control study in a large cohort of patients with a clinical suspicion of having pulmonary embolism. Blood samples were collected to investigate the presence of influenza A and B by complement fixation assay (CFA). We compared case patients, in whom pulmonary embolism was proven (n = 102), to controls, in whom pulmonary embolism was excluded (n = 395). Furthermore, we compared symptoms of influenza-like illness in both patient groups 2 weeks prior to inclusion in the study, using the influenza-like illness (ILI) score, which is based on a questionnaire. We calculated the risk of pulmonary embolism associated with influenza infection.

RESULTS: The percentage of patients with influenza A was higher in the control group compared to the case group (4.3% versus 1.0%, respectively, odds ratio 0.22; 95% CI: 0.03-1.72). Influenza B was not detectable in any of the cases and was found in 3 of the 395 controls (0.8%). The ILI score was positive in 24% of the cases and 25% in the control persons (odds ratio 1.16, 95% CI: 0.67-2.01). We did not observe an association between the ILI score and proven influenza infection.

CONCLUSION: In this clinical study, influenza infection was not associated with an increased risk of acute pulmonary embolism. The ILI score is non-specific in this clinical setting.

References

  1. Arch Intern Med. 1998 Mar 23;158(6):585-93 - PubMed
  2. Presse Med. 2004 Dec 4;33(21):1493-6 - PubMed
  3. Neth J Med. 2005 Apr;63(4):129-36 - PubMed
  4. Thromb Haemost. 2000 Jun;83(6):887-91 - PubMed
  5. Eur J Clin Invest. 2002 Oct;32(10):759-66 - PubMed
  6. Thromb Haemost. 2000 Aug;84(2):319-24 - PubMed
  7. Pathophysiol Haemost Thromb. 2002 Sep-Dec;32(5-6):346-8 - PubMed
  8. Br J Haematol. 2002 Jan;116(1):173-7 - PubMed
  9. J Clin Microbiol. 1999 Dec;37(12):3971-4 - PubMed
  10. Clin Infect Dis. 2000 Nov;31(5):1166-9 - PubMed
  11. Arch Intern Med. 2000 Nov 27;160(21):3243-7 - PubMed
  12. Acad Emerg Med. 2004 Jun;11(6):642-7 - PubMed
  13. J Thromb Haemost. 2007 Jul;5(7):1567-9 - PubMed
  14. Pathology. 2002 Apr;34(2):115-25 - PubMed
  15. Lancet. 2006 Apr 1;367(9516):1075-1079 - PubMed
  16. J Thromb Haemost. 2004 Jul;2(7):1110-7 - PubMed
  17. Thromb Res. 2004;114(5-6):321-7 - PubMed

Publication Types