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Cooper CL, Badley AD, Angel JB. Characteristics of hepatitis C virus infection in HIV-infected people. Can J Infect Dis. 2001;12(3):157-63doi: 10.1155/2001/542056.
Cooper, C. L., Badley, A. D., & Angel, J. B. (2001). Characteristics of hepatitis C virus infection in HIV-infected people. The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses, 12(3), 157-63. https://doi.org/10.1155/2001/542056
Cooper, C L, et al. "Characteristics of hepatitis C virus infection in HIV-infected people." The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses vol. 12,3 (2001): 157-63. doi: https://doi.org/10.1155/2001/542056
Cooper CL, Badley AD, Angel JB. Characteristics of hepatitis C virus infection in HIV-infected people. Can J Infect Dis. 2001 May;12(3):157-63. doi: 10.1155/2001/542056. PMID: 18159334; PMCID: PMC2094812.
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Can J Infect Dis. 2001 May;12(3):157-63. doi: 10.1155/2001/542056.

Characteristics of hepatitis C virus infection in HIV-infected people.

The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses

C L Cooper, A D Badley, J B Angel

Affiliations

  1. Division of Infectious Diseases, Ottawa Hospital General Campus, Ottawa, Ontario;

PMID: 18159334 PMCID: PMC2094812 DOI: 10.1155/2001/542056

Abstract

Knowledge pertaining to hepatitis C virus (HCV)/human immunodeficiency virus (HIV) co-infection is currently incomplete or conflicting. Several points are well studied, however. Plasma HCV RNA levels are higher in matched HIV-infected people than in HIV-seronegative control subjects and are inversely correlated with CD4(+) T lymphocyte counts. HCV genotype does not appear to influence this value. Co-infected individuals develop histological and clinical features of HCV liver disease more rapidly than HIV-seronegative patients. Co-infected individuals appear to respond to interferon-alpha therapy equally as well as HIV-seronegative HCV-infected adults, but minimal information exists regarding the efficacy and toxicity of combination HCV therapy (interferon-alpha plus ribavirin) in this population. Adverse consequences of highly active antiretroviral therapy in co-infected patients include hepatic toxicity and, in a minority of patients, an 'immune restoration syndrome'. It is unclear whether long term, highly active antiretroviral therapy positively or negatively influences the natural history of HCV infection.

Keywords: Antiretrovirals; HCV; HIV; Hepatitis; Hepatitis C virus; Human immunodeficiency virus

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