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Watts TH, Bertram EM, Bukczynski J, et al. T cell costimulatory molecules in anti-viral immunity: Potential role in immunotherapeutic vaccines. Can J Infect Dis. 2003;14(4):221-9doi: 10.1155/2003/214034.
Watts, T. H., Bertram, E. M., Bukczynski, J., & Wen, T. (2003). T cell costimulatory molecules in anti-viral immunity: Potential role in immunotherapeutic vaccines. The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses, 14(4), 221-9. https://doi.org/10.1155/2003/214034
Watts, Tania H, et al. "T cell costimulatory molecules in anti-viral immunity: Potential role in immunotherapeutic vaccines." The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses vol. 14,4 (2003): 221-9. doi: https://doi.org/10.1155/2003/214034
Watts TH, Bertram EM, Bukczynski J, Wen T. T cell costimulatory molecules in anti-viral immunity: Potential role in immunotherapeutic vaccines. Can J Infect Dis. 2003 Jul;14(4):221-9. doi: 10.1155/2003/214034. PMID: 18159461; PMCID: PMC2094939.
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Can J Infect Dis. 2003 Jul;14(4):221-9. doi: 10.1155/2003/214034.

T cell costimulatory molecules in anti-viral immunity: Potential role in immunotherapeutic vaccines.

The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses

Tania H Watts, Edward M Bertram, Jacob Bukczynski, Tao Wen

PMID: 18159461 PMCID: PMC2094939 DOI: 10.1155/2003/214034

Abstract

T lymphocyte activation is required to eliminate or control intracellular viruses. The activation of T cells requires both an antigen specific signal, involving the recognition of a peptide/major histocompatibility protein complex by the T cell receptor, as well as additional costimulatory signals. In chronic viral diseases, T cell responses, although present, are unable to eliminate the infection. By providing antigens and costimulatory molecules together, investigators may be able to increase and broaden the immune response, resulting in better immunological control or even elimination of the infection. Recent progress in understanding the function of costimulatory molecules suggests that different costimulatory molecules are involved in initial immune responses than are involved in recall responses. These new developments have important implications for therapeutic vaccine design. In this review the authors discuss the function of T cell costimulatory molecules in immune system activation and their potential for enhancing the efficacy of therapeutic vaccines.

Keywords: Immunity; Lymphocytes; Therapeutic vaccines; Vaccination; Viral infection

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