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Zwarenstein MF, Dainty KN, Quan S, et al. A cluster randomized trial evaluating electronic prescribing in an ambulatory care setting. Trials. 2007;8:28doi: 10.1186/1745-6215-8-28.
Zwarenstein, M. F., Dainty, K. N., Quan, S., Kiss, A., & Adhikari, N. K. (2007). A cluster randomized trial evaluating electronic prescribing in an ambulatory care setting. Trials, 828. https://doi.org/10.1186/1745-6215-8-28
Zwarenstein, Merrick F, et al. "A cluster randomized trial evaluating electronic prescribing in an ambulatory care setting." Trials vol. 8 (2007): 28. doi: https://doi.org/10.1186/1745-6215-8-28
Zwarenstein MF, Dainty KN, Quan S, Kiss A, Adhikari NK. A cluster randomized trial evaluating electronic prescribing in an ambulatory care setting. Trials. 2007 Oct 03;8:28. doi: 10.1186/1745-6215-8-28. PMID: 17915028; PMCID: PMC2092426.
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Trials. 2007 Oct 03;8:28. doi: 10.1186/1745-6215-8-28.

A cluster randomized trial evaluating electronic prescribing in an ambulatory care setting.

Trials

Merrick F Zwarenstein, Katie N Dainty, Sherman Quan, Alex Kiss, Neill K J Adhikari

Affiliations

  1. Institute For Clinical Evaluative Sciences and The Clinical Epidemiology Unit, Center For Health Services Sciences, Sunnybrook Hospital, Ontario, Canada. [email protected]

PMID: 17915028 PMCID: PMC2092426 DOI: 10.1186/1745-6215-8-28

Abstract

BACKGROUND: Medication errors, adverse drug events and potential adverse drug events are common and serious in terms of the harms and costs that they impose on the health system and those who use it. Errors resulting in preventable adverse drug events have been shown to occur most often at the stages of ordering and administration. This paper describes the protocol for a pragmatic trial of electronic prescribing to reduce prescription error. The trial was designed to overcome the limitations associated with traditional study design.

DESIGN: This study was designed as a 65-week, cluster randomized, parallel study.

METHODS: The trial was conducted within ambulatory outpatient clinics in an academic tertiary care centre in Ontario, Canada. The electronic prescribing software for the study is a Canadian electronic prescribing software package which provides physician prescription entry with decision support at the point of care. Using a handheld computer (PDA) the physician selects medications using an error minimising menu-based pick list from a comprehensive drug database, create specific prescription instructions and then transmit the prescription directly and electronically to a participating pharmacy via facsimile or to the physician's printer using local area wireless technology. The unit of allocation and randomization is by 'week', i.e. the system is "on" or "off" according to the randomization scheme and the unit of analysis is the prescription, with adjustment for clustering of patients within practitioners.

DISCUSSION: This paper describes the protocol for a pragmatic cluster randomized trial of point-of-care electronic prescribing, which was specifically designed to overcome the limitations associated with traditional study design.

TRIAL REGISTRATION: This trial has been registered with clinicaltrials.gov (ID: NCT00252395).

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