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Sullivan RM, Wilson DA. The role of norepinephrine in the expression of learned olfactory neurobehavioral responses in infant rats. Psychobiology (Austin, Tex). 1991;19(4):308-312doi: 10.3758/bf03332084.
Sullivan, R. M., & Wilson, D. A. (1991). The role of norepinephrine in the expression of learned olfactory neurobehavioral responses in infant rats. Psychobiology (Austin, Tex.), 19(4), 308-312. https://doi.org/10.3758/bf03332084
Sullivan, R M, and Wilson, D A. "The role of norepinephrine in the expression of learned olfactory neurobehavioral responses in infant rats." Psychobiology (Austin, Tex.) vol. 19,4 (1991): 308-312. doi: https://doi.org/10.3758/bf03332084
Sullivan RM, Wilson DA. The role of norepinephrine in the expression of learned olfactory neurobehavioral responses in infant rats. Psychobiology (Austin, Tex). 1991;19(4):308-312. doi: 10.3758/bf03332084. PMID: 18172513; PMCID: PMC2173628.
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Psychobiology (Austin, Tex). 1991;19(4):308-312. doi: 10.3758/bf03332084.

The role of norepinephrine in the expression of learned olfactory neurobehavioral responses in infant rats.

Psychobiology (Austin, Tex.)

R M Sullivan, D A Wilson

Affiliations

  1. University of Oklahoma, Norman, Oklahoma.

PMID: 18172513 PMCID: PMC2173628 DOI: 10.3758/bf03332084

Abstract

In neonatal rats, norepinephrine (NE) is necessary and sufficient for the acquisition of an olfactory preference and its associated olfactory bulb neural modifications as assessed by [(14)C] 2-deoxyglucose (2-DG) and electrophysiology. In the present studies, we assessed the influence of NE on the expression of a conditioned odor preference and its associated olfactory bulb neural modifications in neonatal rats. On Postnatal Day 5 (PN 5), pups were trained to prefer an odor in a 1-h classical conditioning paradigm. Experimental paired odor-stroke pups received 20 forward pairings of a 10-sec peppermint odor and a 9-sec reinforcing tactile stimulation (stroking). Control pups received either random stroke-odor pairings or were naive (received neither the odor nor stroking). The next day (PN 6), the pups were injected with either an NE β-receptor antagonist, (propranolol or timolol) or saline, 1 h prior to testing. The pups were tested for a behavioral olfactory preference and assessed for differential olfactory bulb activity with [(14)C] 2-DG autoradiography. The results indicate that NE is not necessary for the expression of the learned neurobehavioral response.

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