Display options
Cite
Lungu V, Niculae D, Mihailescu G, et al. Biomathematical approach of (188)Re radiopharmaceutical therapy characterization. J BUON. 2002;7(4):365-71
Lungu, V., Niculae, D., Mihailescu, G., Baiculescu, S., Turcu, I., & Danaila, L. (2002). Biomathematical approach of (188)Re radiopharmaceutical therapy characterization. Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 7(4), 365-71.
Lungu, V, et al. "Biomathematical approach of (188)Re radiopharmaceutical therapy characterization." Journal of B.U.ON. : official journal of the Balkan Union of Oncology vol. 7,4 (2002): 365-71.
Lungu V, Niculae D, Mihailescu G, Baiculescu S, Turcu I, Danaila L. Biomathematical approach of (188)Re radiopharmaceutical therapy characterization. J BUON. 2002 Oct-Dec;7(4):365-71. PMID: 17955582.
Copy Download .nbib Format: NLM
Share it on

J BUON. 2002 Oct-Dec;7(4):365-71.

Biomathematical approach of (188)Re radiopharmaceutical therapy characterization.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology

V Lungu, D Niculae, G Mihailescu, S Baiculescu, I Turcu, L Danaila

Affiliations

  1. "Horia Hulubei" Institute for Physics and Nuclear Engineering, Bucharest, Romania.

PMID: 17955582

Abstract

PURPOSE: In order to optimize radioimmunotherapy (RIT) as a cancer treatment modality, it is necessary to select the appropriate radionuclide and the biomolecule carrier. We have developed the radiolabeling with (188)Re (beta emitter) of anti-carcinoembryonic antigen (CEA) monoclonal antibody (Mab) for targeting CEA-producing tumors.

MATERIALS AND METHODS: Labeling was realized by the addition of Na(188)ReO(4) eluted from (188)W- (188)Re generator to a preformulated biomolecule in SH prereduction form in the presence of supplemental stannous ions. Wistar London rats were used for the biological studies. For the mathematical processing of the obtained results we used interpolation functions, as well as the different organs under investigation. Used were those interpolation functions for which the standard error is zero, correlation coefficient is the unit and the analytic expression emphasize generally exponential forms (the differential equations specific to the radioactive biodistribution have exponential integral curves as solutions).

RESULTS: The achieved radiochemical purity was 92-96%. The resulting solutions had a pH value 5-7 and were used for intravenous (i.v.) administration. The optimum field of interpolation functions was determined, comprising Hoerl, Modified Hoerl, Heart Capacity, Gaussian, Logistic, and Exponential type models. The optimum model existing in that field was also determined in the condition in which the ratio between absolute error of the biodistribution surface/the mean surface of the optimum biodistribution was minimal.

CONCLUSION: The obtained optimum model has a predictive character, allowing the identification of the moment to which the maximum percent value for every other time point in the considered time interval t(o)-t(f). This mathematical model can be used for every other pharmacokinetic paradigm.

Publication Types