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Wirkowski E, Libman RB, Batash M. Hashimot's encephalopathy-response to intravenous immunoglobulin. J Stroke Cerebrovasc Dis. 1998;7(4):265-6doi: 10.1016/s1052-3057(98)80038-4.
Wirkowski, E., Libman, R. B., & Batash, M. (1998). Hashimot's encephalopathy-response to intravenous immunoglobulin. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 7(4), 265-6. https://doi.org/10.1016/s1052-3057(98)80038-4
Wirkowski, E, et al. "Hashimot's encephalopathy-response to intravenous immunoglobulin." Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association vol. 7,4 (1998): 265-6. doi: https://doi.org/10.1016/s1052-3057(98)80038-4
Wirkowski E, Libman RB, Batash M. Hashimot's encephalopathy-response to intravenous immunoglobulin. J Stroke Cerebrovasc Dis. 1998 Jul-Aug;7(4):265-6. doi: 10.1016/s1052-3057(98)80038-4. PMID: 17895096.
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J Stroke Cerebrovasc Dis. 1998 Jul-Aug;7(4):265-6. doi: 10.1016/s1052-3057(98)80038-4.

Hashimot's encephalopathy-response to intravenous immunoglobulin.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

E Wirkowski, R B Libman, M Batash

Affiliations

  1. Department of Neurology, Long Island Jewish Medical Center, New Hyde Park, NY, USA.

PMID: 17895096 DOI: 10.1016/s1052-3057(98)80038-4

Abstract

BACKGROUND: Hashimoto's encephalopathy is an unusual brain disorder consisting of focal and diffuse cerebral dysfunction that may present in a stroke-like fashion. Treatment has consisted of steroids and immunosuppression. Treatment with a potentially less toxic modality such as intravenous immunoglobulin (IVIG), if found to be effective, might offer an alternative approach to these patients.

CASE DESCRIPTION: We present an 82-year-old woman who developed headache, changes in mental status, and multifocal neurological deficits. Investigation revealed significantly elevated titers of antithyroid antibodies. Treatment with prednisone and methotrexate was unsuccessful. Treatment with monthly courses of IVIG resulted in marked clinical improvement.

CONCLUSION: Hashimoto's encephalopathy may be more common than is generally recognized. A trial of IVIG should be considered for patients with this devastating condition.

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