J Stroke Cerebrovasc Dis. 1998 Nov-Dec;7(6):398-403. doi: 10.1016/s1052-3057(98)80123-7.
Extensive hemispheric cerebral infarction.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
C R Levi, S J Read, T Hirano, G A Donnan
PMID: 17895118
DOI: 10.1016/s1052-3057(98)80123-7
Abstract
BACKGROUND AND PURPOSE: Patients with extensive hemispheric cerebral infarction have a high incidence of mortality and serious morbidity. Because of their poor prognosis, they warrant attention; however, in acute stroke therapy trials they do not appear to benefit from treatment. We sought to determine the clinical features, pathophysiological mechanisms, and outcome in a series of cases with radiologically defined extensive hemispheric infarction.
METHODS: Cases of extensive hemispheric infarction were ascretained retrospectively from stroke admissions during a 5-year period. Extensive hemispheric infarction was defined radiologically as infarction involving greater than 75% of the middle cerebral artery territory, with or without involvement of the adjacent anterior or posterior cerebral artery territories. Clinical, risk factor, and stroke mechanism data were compared with that of a control group of ischemic stroke patients admitted during the same period.
RESULTS: Extensive hemispheric infarction occurred in 53 of 1,440 cases of ischemic stroke (3.7%). Infarction involved the middle cerebral artery territory alone in 79% of cases, and the adjacent anterior or posterior cerebral artery territories as well as 21% of cases. A cardioembolic mechanism was likely in 58% of cases; 42% had atrial fibrillation. When compared with the control group, a cardioembolic mechanism was the only feature more frequently associated with extensive hemispheric infarction. The overall in-hospital mortality rate was 52%; 84% of those discharged from hospital required nursing home care because of severe disability.
CONCLUSION: Although uncommon, extensive hemispheric infarction is an important stroke subtype with dramatic and easily recognizable presenting clinical features, frequent cardio-embolic mechanism, an extremely poor outcome, and failure to benefit from most experimental acute stroke therapies.
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