Display options
Cite
Houston MC, Cooil B, Olafsson BJ, et al. Juice powder concentrate and systemic blood pressure, progression of coronary artery calcium and antioxidant status in hypertensive subjects: a pilot study. Evid Based Complement Alternat Med. 2007;4(4):455-62doi: 10.1093/ecam/nel108.
Houston, M. C., Cooil, B., Olafsson, B. J., & Raggi, P. (2007). Juice powder concentrate and systemic blood pressure, progression of coronary artery calcium and antioxidant status in hypertensive subjects: a pilot study. Evidence-based complementary and alternative medicine : eCAM, 4(4), 455-62. https://doi.org/10.1093/ecam/nel108
Houston, M C, et al. "Juice powder concentrate and systemic blood pressure, progression of coronary artery calcium and antioxidant status in hypertensive subjects: a pilot study." Evidence-based complementary and alternative medicine : eCAM vol. 4,4 (2007): 455-62. doi: https://doi.org/10.1093/ecam/nel108
Houston MC, Cooil B, Olafsson BJ, Raggi P. Juice powder concentrate and systemic blood pressure, progression of coronary artery calcium and antioxidant status in hypertensive subjects: a pilot study. Evid Based Complement Alternat Med. 2007 Dec;4(4):455-62. doi: 10.1093/ecam/nel108. PMID: 18227913; PMCID: PMC2176151.
Copy Download .nbib Format: NLM
Share it on

Evid Based Complement Alternat Med. 2007 Dec;4(4):455-62. doi: 10.1093/ecam/nel108.

Juice powder concentrate and systemic blood pressure, progression of coronary artery calcium and antioxidant status in hypertensive subjects: a pilot study.

Evidence-based complementary and alternative medicine : eCAM

M C Houston, B Cooil, B J Olafsson, P Raggi

Affiliations

  1. Hypertension Institute of Nashville, Vanderbilt University School of Medicine and Saint Thomas Hospital, Owen Graduate School of Management, Vanderbilt University, The Heart Group, Saint Thomas Heart Institute and Saint Thomas Hospital, Nashville, TN and Department of Medicine and Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA.

PMID: 18227913 PMCID: PMC2176151 DOI: 10.1093/ecam/nel108

Abstract

Because micronutrients from plants may have beneficial cardiovascular effects, the hypothesis that an encapsulated juice powder concentrate might affect several measures of vascular health was tested in free living adults at low cardiovascular risk. Blood pressure, vascular compliance, lipid and antioxidant markers, and serial electron beam tomography (to calculate a coronary artery calcium score as a measure of atherosclerosis burden), were monitored in 51 pre-hypertensive and hypertensive subjects over 2 years. By the end of follow-up, systolic and diastolic blood pressure decreased significantly (-2.4 +/- 1.0 mmHg, P < 0.05 and -2.2 +/- 0.6 mmHg, P < 0.001), and large artery compliance improved significantly (1.9 +/- 0.6 ml mmHg(-1) x 100, P < 0.01). The progression of coronary artery calcium score was smaller than expected compared with a historical database (P < 0.001). Laboratory testing showed a significant decrease in homocysteine (P = 0.05), HDL cholesterol (P = 0.025) and Apo A (P = 0.004), as well as a significant increase in beta-carotene, folate, Co-Q10 and alpha-tocopherol (all P < 0.001). The phytonutrient concentrate we utilized induced several favorable modifications of markers of vascular health in the subjects. This study supports the notion that plant nutrients are important components of a heart healthy diet.

Keywords: antioxidant; blood pressure; coronary artery calcium; fruit; hypertension; vegetable

References

  1. Ann Intern Med. 2001 Jun 19;134(12):1106-14 - PubMed
  2. Circulation. 2004 Apr 6;109(13):1609-14 - PubMed
  3. Am J Clin Nutr. 2004 Jun;79(6):1060-72 - PubMed
  4. Arch Intern Med. 2004 Feb 23;164(4):370-6 - PubMed
  5. N Engl J Med. 1993 May 20;328(20):1450-6 - PubMed
  6. J Am Diet Assoc. 2004 Nov;104(11):1725-7 - PubMed
  7. Circulation. 2004 Feb 10;109(5):672-93 - PubMed
  8. Circulation. 2003 Feb 25;107(7):947-53 - PubMed
  9. Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):554-66 - PubMed
  10. Jpn Circ J. 2001 Mar;65(3):200-6 - PubMed
  11. Am J Cardiol. 2000 Feb 10;85(3A):3A-9A - PubMed
  12. Circulation. 2003 Jan 7;107(1):149-58 - PubMed
  13. J Nutr. 2004 Jul;134(7):1806-11 - PubMed
  14. Kidney Int. 2002 Jul;62(1):245-52 - PubMed
  15. Hypertension. 2005 Jul;46(1):238-43 - PubMed
  16. Lancet. 2000 Oct 7;356(9237):1213-8 - PubMed
  17. N Engl J Med. 1993 May 20;328(20):1444-9 - PubMed
  18. Evid Based Complement Alternat Med. 2006 Jun;3(2):229-35 - PubMed
  19. N Engl J Med. 2000 Jan 20;342(3):154-60 - PubMed
  20. Arch Intern Med. 2004 Jun 28;164(12):1285-92 - PubMed
  21. Lancet. 1997 Jun 14;349(9067):1715-20 - PubMed
  22. Lancet. 1996 Mar 23;347(9004):781-6 - PubMed
  23. Radiology. 1998 Sep;208(3):807-14 - PubMed
  24. Curr Atheroscler Rep. 2004 Mar;6(2):107-11 - PubMed
  25. JAMA. 2004 Jan 14;291(2):210-5 - PubMed
  26. BMC Med Imaging. 2004 Apr 26;4(1):1 - PubMed
  27. BMJ. 1998 Nov 14;317(7169):1341-5 - PubMed
  28. Am J Clin Nutr. 2003 Sep;78(3 Suppl):533S-538S - PubMed
  29. J Am Coll Cardiol. 1990 Mar 15;15(4):827-32 - PubMed
  30. Lancet. 2002 Jul 6;360(9326):23-33 - PubMed
  31. J Nutr. 2004 Apr;134(4):913-8 - PubMed
  32. Ann Intern Med. 2005 May 3;142(9):725-33 - PubMed
  33. Lancet. 1999 Aug 7;354(9177):447-55 - PubMed
  34. Eur J Clin Nutr. 1998 Aug;52(8):549-56 - PubMed
  35. N Engl J Med. 1998 Dec 31;339(27):1972-8 - PubMed
  36. JAMA. 1998 Dec 16;280(23):2001-7 - PubMed
  37. Am J Cardiol. 2001 Jan 15;87(2):210-3, A8 - PubMed
  38. Circulation. 2000 Feb 29;101(8):850-5 - PubMed
  39. Lancet. 1993 Oct 23;342(8878):1007-11 - PubMed
  40. J Am Coll Cardiol. 2003 May 21;41(10):1744-9 - PubMed
  41. Circulation. 2002 Sep 17;106(12):1453-9 - PubMed
  42. Am J Clin Nutr. 1999 Sep;70(3):412-9 - PubMed
  43. Am J Cardiol. 2003 Oct 1;92(7):827-9 - PubMed
  44. Epidemiology. 2001 Jan;12(1):62-7 - PubMed
  45. Am J Hypertens. 2005 Jan;18(1):65-71 - PubMed

Publication Types