Heart Fail Clin. 2007 Oct;3(4):437-53. doi: 10.1016/j.hfc.2007.07.008.
Heart failure clinics
Dalane W Kitzman, Kurt R Daniel
PMID: 17905379 DOI: 10.1016/j.hfc.2007.07.008
Most elderly patients, particularly women, who have heart failure have a normal ejection fraction. Patients who have this syndrome have severe symptoms of exercise intolerance, frequent hospitalizations, and increased mortality. The pathophysiology and treatment are not well defined. Control of systemic hypertension may be a key to prevention and treatment. Several large trials of specific agents are currently underway.