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Curra FP, Mourad PD, Khokhlova VA, et al. Numerical simulations of heating patterns and tissue temperature response due to high-intensity focused ultrasound. IEEE Trans Ultrason Ferroelectr Freq Control. 2000;47(4):1077-89doi: 10.1109/58.852092.
Curra, F. P., Mourad, P. D., Khokhlova, V. A., Cleveland, R. O., & Crum, L. A. (2000). Numerical simulations of heating patterns and tissue temperature response due to high-intensity focused ultrasound. IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 47(4), 1077-89. https://doi.org/10.1109/58.852092
Curra, F P, et al. "Numerical simulations of heating patterns and tissue temperature response due to high-intensity focused ultrasound." IEEE transactions on ultrasonics, ferroelectrics, and frequency control vol. 47,4 (2000): 1077-89. doi: https://doi.org/10.1109/58.852092
Curra FP, Mourad PD, Khokhlova VA, Cleveland RO, Crum LA. Numerical simulations of heating patterns and tissue temperature response due to high-intensity focused ultrasound. IEEE Trans Ultrason Ferroelectr Freq Control. 2000;47(4):1077-89. doi: 10.1109/58.852092. PMID: 18238643.
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IEEE Trans Ultrason Ferroelectr Freq Control. 2000;47(4):1077-89. doi: 10.1109/58.852092.

Numerical simulations of heating patterns and tissue temperature response due to high-intensity focused ultrasound.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control

F P Curra, P D Mourad, V A Khokhlova, R O Cleveland, L A Crum

Affiliations

  1. Appl. Phys. Lab., Washington Univ., Seattle, WA.

PMID: 18238643 DOI: 10.1109/58.852092

Abstract

The results of this paper show-for an existing high intensity, focused ultrasound (HIFU) transducer-the importance of nonlinear effects on the space/time properties of wave propagation and heat generation in perfused liver models when a blood vessel also might be present. These simulations are based on the nonlinear parabolic equation for sound propagation and the bio-heat equation for temperature generation. The use of high initial pressure in HIFU transducers in combination with the physical characteristics of biological tissue induces shock formation during the propagation of a therapeutic ultrasound wave. The induced shock directly affects the rate at which heat is absorbed by tissue at the focus without significant influence on the magnitude and spatial distribution of the energy being delivered. When shocks form close to the focus, nonlinear enhancement of heating is confined in a small region around the focus and generates a higher localized thermal impact on the tissue than that predicted by linear theory. The presence of a blood vessel changes the spatial distribution of both the heating rate and temperature.

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