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Org Lett. 2006 Feb 02;8(3):383-5. doi: 10.1021/ol0524757.

Synthesis of 3,6-diaminophthalimides for ureidophthalimide-based foldamers.

Organic letters

Renatus W Sinkeldam, Michel H C J van Houtem, Guy Koeckelberghs, Jef A J M Vekemans, E W Meijer

Affiliations

  1. Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.

PMID: 16435840 DOI: 10.1021/ol0524757

Abstract

[reaction: see text]. Herein, we report an improved methodology for the synthesis of a variety of 3,6-diaminophthalimides in high yields. This enables decoration of the periphery of foldamers with a wide range of functionalities.

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