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Vömel T. The elimination of aged glycoproteins by the isolated perfused rat liver. Arch Gerontol Geriatr. 1997;25(1):141-6doi: 10.1016/s0167-4943(96)00779-0.
Vömel, T. (1997). The elimination of aged glycoproteins by the isolated perfused rat liver. Archives of gerontology and geriatrics, 25(1), 141-6. https://doi.org/10.1016/s0167-4943(96)00779-0
Vömel, T. "The elimination of aged glycoproteins by the isolated perfused rat liver." Archives of gerontology and geriatrics vol. 25,1 (1997): 141-6. doi: https://doi.org/10.1016/s0167-4943(96)00779-0
Vömel T. The elimination of aged glycoproteins by the isolated perfused rat liver. Arch Gerontol Geriatr. 1997 Jul-Aug;25(1):141-6. doi: 10.1016/s0167-4943(96)00779-0. PMID: 15374109.
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Arch Gerontol Geriatr. 1997 Jul-Aug;25(1):141-6. doi: 10.1016/s0167-4943(96)00779-0.

The elimination of aged glycoproteins by the isolated perfused rat liver.

Archives of gerontology and geriatrics

T Vömel

Affiliations

  1. Hüttenhospital Dortmund Hörde, Department Internal Medicine - Geriatrie, Am Marksbach 28, D-44269 Dortmund, Germany.

PMID: 15374109 DOI: 10.1016/s0167-4943(96)00779-0

Abstract

The isolated livers of Sprague-Dawley rats aged ten months were perfused with nine different glycoproteins (coeruloplasmine, haptoglobin, transferrin, alpha2-mocroglobulin, apolipoprotein A, plasminogen, acid alpha1-glycoprotein, alpha1-antitrypsin, beta2-glycoprotein), which were suspended in a basic medium free of hemoglobin and other proteins. Besides a control group two other groups were formed to give a model for aging: one group of glycoproteins was desialysed, another was desilysed and incubated with immunoglobulins before the perfusion. In spite of the application of two procedures which are supposed to produce a model of old glycoproteins, neither treatment resulted in the recognition, binding and elimination of the glycoproteins from the perfusion medium.

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