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Lennox SD, Sykesa D, Penney M, et al. Influence of orthostatic hypotension in Parkinson's disease on plasma atrial natriuretic peptide. Arch Gerontol Geriatr. 1995;21(3):317-20doi: 10.1016/0167-4943(95)00671-7.
Lennox, S. D., Sykesa, D., Penney, M., Hampton, D., & Woodhouse, K. (1995). Influence of orthostatic hypotension in Parkinson's disease on plasma atrial natriuretic peptide. Archives of gerontology and geriatrics, 21(3), 317-20. https://doi.org/10.1016/0167-4943(95)00671-7
Lennox, S D, et al. "Influence of orthostatic hypotension in Parkinson's disease on plasma atrial natriuretic peptide." Archives of gerontology and geriatrics vol. 21,3 (1995): 317-20. doi: https://doi.org/10.1016/0167-4943(95)00671-7
Lennox SD, Sykesa D, Penney M, Hampton D, Woodhouse K. Influence of orthostatic hypotension in Parkinson's disease on plasma atrial natriuretic peptide. Arch Gerontol Geriatr. 1995 Nov-Dec;21(3):317-20. doi: 10.1016/0167-4943(95)00671-7. PMID: 15374207.
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Arch Gerontol Geriatr. 1995 Nov-Dec;21(3):317-20. doi: 10.1016/0167-4943(95)00671-7.

Influence of orthostatic hypotension in Parkinson's disease on plasma atrial natriuretic peptide.

Archives of gerontology and geriatrics

S D Lennox, D Sykesa, M Penney, D Hampton, K Woodhouse

Affiliations

  1. Department of Geriatrics, Glan Hafren NHS Trust, Newport, Gwent, UK.

PMID: 15374207 DOI: 10.1016/0167-4943(95)00671-7

Abstract

The effect of orthostatic hypotension in Parkinson's disease (PD) on plasma atrial natriuretic peptide (ANP) was examined in fifteen individuals with PD without autonomic dysfunction (63-85 years), nine PD patients with autonomic dysfunction (orthostatic hypotension; systolic BP change > 20 mmHg after 5 min standing: 69-82 years) and 14 fit elderly volunteers (62-93 years). The mean ANP level was 42.2 pg/ml (range 16.8-89.2 pg/ml) in the PD group without autonomic dysfunction; 44.4 pg/ml (range 27.2-91.2 pg/ml) in the PD group with autonomic dysfunction; and 48.5 pg/ml (range 22.2-111.6 pg/ml) in the elderly group. There was no statistical difference in plasma atrial natriuretic peptide between all three groups. The mean change in blood pressure was -39 mmHg (systolic) and -18 mmHg (diastolic) between supine and standing in the group with orthostatic hypotension.

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