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Pieri C, Marra M, Moroni F, et al. The modulation of intracellular glutathione level modulates the mitochondrial response in proliferating rat splenocytes. Arch Gerontol Geriatr. 1995;21(2):115-25doi: 10.1016/0167-4943(95)00630-4.
Pieri, C., Marra, M., Moroni, F., Marcheselli, F., & Benatti, C. (1995). The modulation of intracellular glutathione level modulates the mitochondrial response in proliferating rat splenocytes. Archives of gerontology and geriatrics, 21(2), 115-25. https://doi.org/10.1016/0167-4943(95)00630-4
Pieri, C, et al. "The modulation of intracellular glutathione level modulates the mitochondrial response in proliferating rat splenocytes." Archives of gerontology and geriatrics vol. 21,2 (1995): 115-25. doi: https://doi.org/10.1016/0167-4943(95)00630-4
Pieri C, Marra M, Moroni F, Marcheselli F, Benatti C. The modulation of intracellular glutathione level modulates the mitochondrial response in proliferating rat splenocytes. Arch Gerontol Geriatr. 1995 Sep-Oct;21(2):115-25. doi: 10.1016/0167-4943(95)00630-4. PMID: 15374208.
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Arch Gerontol Geriatr. 1995 Sep-Oct;21(2):115-25. doi: 10.1016/0167-4943(95)00630-4.

The modulation of intracellular glutathione level modulates the mitochondrial response in proliferating rat splenocytes.

Archives of gerontology and geriatrics

C Pieri, M Marra, F Moroni, F Marcheselli, C Benatti

Affiliations

  1. Cytology Center, Gerontological Research Department of I.N.R.C.A., Via Birarelli no. 8, 60121 Ancona, Italy.

PMID: 15374208 DOI: 10.1016/0167-4943(95)00630-4

Abstract

We have investigated the effect of intracellular reduced glutathione (GSH) levels on the mitochondrial parameters of proliferating rat splenocytes. The intracellular GSH content of the cells was altered by continuous culture with buthionine-S, R-sulfoximine (BSO), a specific inhibitor of GSH synthesis. BSO decreased the GSH levels, inhibited DNA synthesis and caused depolarization of mitochondria in 52% of cells stimulated to proliferate for 72 h. These data support the proposition that GSH influences the lymphocyte proliferation at more than one site, one of which is the energy producing machinery.

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