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Amenta F, Cavallotti C, de Michele M, et al. Changes of dopamine-sensitive cyclic AMP-generating system in the rat hippocampus as a function of age. Arch Gerontol Geriatr. 1990;10(3):279-85doi: 10.1016/0167-4943(90)90029-6.
Amenta, F., Cavallotti, C., de Michele, M., Ricci, A., & Vega, J. A. (1990). Changes of dopamine-sensitive cyclic AMP-generating system in the rat hippocampus as a function of age. Archives of gerontology and geriatrics, 10(3), 279-85. https://doi.org/10.1016/0167-4943(90)90029-6
Amenta, F, et al. "Changes of dopamine-sensitive cyclic AMP-generating system in the rat hippocampus as a function of age." Archives of gerontology and geriatrics vol. 10,3 (1990): 279-85. doi: https://doi.org/10.1016/0167-4943(90)90029-6
Amenta F, Cavallotti C, de Michele M, Ricci A, Vega JA. Changes of dopamine-sensitive cyclic AMP-generating system in the rat hippocampus as a function of age. Arch Gerontol Geriatr. 1990 May-Jun;10(3):279-85. doi: 10.1016/0167-4943(90)90029-6. PMID: 15374503.
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Arch Gerontol Geriatr. 1990 May-Jun;10(3):279-85. doi: 10.1016/0167-4943(90)90029-6.

Changes of dopamine-sensitive cyclic AMP-generating system in the rat hippocampus as a function of age.

Archives of gerontology and geriatrics

F Amenta, C Cavallotti, M de Michele, A Ricci, J A Vega

Affiliations

  1. Dipartimento di Scienze Neurologiche, Universita La Sapienza, Rome, Italy.

PMID: 15374503 DOI: 10.1016/0167-4943(90)90029-6

Abstract

The dopamine (DA) D(1) and D(2) receptors coupled to the 3',5'-cyclic adenosine monophosphate (cAMP)-generating system were studied in membrane particles of the dorsal hippocampus in 3 (considered to be young), 12 (considered to be adult) and 24 (considered to be old) month male Sprague-Dawley rats. Activation of D(1) receptors with DA, apomorphine or SKF 82526 enhanced accumulation of cAMP in the hippocampus of rats of the three age groups examined. This stimulatory effect was significantly reduced in adult rats. No further changes were noticeable in old animals. D(2) receptors negatively coupled to cAMP generation were demonstrated by incubating hippocampus membrane particles with SCH 23390 plus DA or with D(2) receptor agonists quinpirole or bromocriptine. The D(2) inhibitory effect on cAMP generation was unchanged in the three age groups. No difference was detectable between young, adult and old rats in the activation of cAMP production by forskolin.

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