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Attallah AM, Shiha GE, Omran MM, et al. A discriminant score based on four routine laboratory blood tests for accurate diagnosis of severe fibrosis and/or liver cirrhosis in Egyptian patients with chronic hepatitis C. Hepatol Res. 2006;34(3):163-9doi: 10.1016/j.hepres.2005.12.004.
Attallah, A. M., Shiha, G. E., Omran, M. M., & Zalata, K. R. (2006). A discriminant score based on four routine laboratory blood tests for accurate diagnosis of severe fibrosis and/or liver cirrhosis in Egyptian patients with chronic hepatitis C. Hepatology research : the official journal of the Japan Society of Hepatology, 34(3), 163-9. https://doi.org/10.1016/j.hepres.2005.12.004
Attallah, Abdelfattah M, et al. "A discriminant score based on four routine laboratory blood tests for accurate diagnosis of severe fibrosis and/or liver cirrhosis in Egyptian patients with chronic hepatitis C." Hepatology research : the official journal of the Japan Society of Hepatology vol. 34,3 (2006): 163-9. doi: https://doi.org/10.1016/j.hepres.2005.12.004
Attallah AM, Shiha GE, Omran MM, Zalata KR. A discriminant score based on four routine laboratory blood tests for accurate diagnosis of severe fibrosis and/or liver cirrhosis in Egyptian patients with chronic hepatitis C. Hepatol Res. 2006 Mar;34(3):163-9. doi: 10.1016/j.hepres.2005.12.004. Epub 2006 Feb 14. PMID: 16478676.
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Hepatol Res. 2006 Mar;34(3):163-9. doi: 10.1016/j.hepres.2005.12.004. Epub 2006 Feb 14.

A discriminant score based on four routine laboratory blood tests for accurate diagnosis of severe fibrosis and/or liver cirrhosis in Egyptian patients with chronic hepatitis C.

Hepatology research : the official journal of the Japan Society of Hepatology

Abdelfattah M Attallah, Gamal E Shiha, Mohamed M Omran, Khaled R Zalata

Affiliations

  1. Research & Development Deptartment, Biotechnology Research Center, New Damietta City, Egypt.

PMID: 16478676 DOI: 10.1016/j.hepres.2005.12.004

Abstract

Liver biopsy is still recommended in most patients with chronic hepatitis C (CHC). Due to its limitations and risks, the use of non-invasive blood biomarkers has been suggested for predicting liver cirrhosis in these patients. Here, we analyzed a panel of routine blood biochemical and hematological markers of 455 Egyptians (272 males and 183 females aged 26-67 years; mean age of 47.25 years) with clinically confirmed CHC. The multivariate discriminant analysis (MDA) selected a function based on absolute values of the four routine biomarkers; score=[albumin (g/L)x0.3+platelet count (10(9)/L)x0.05]-[alkaline phosphatase (IU/L)x0.014+AST/ALT ratiox6+14]. The MDA function correctly classified 98% of the cirrhotic patients at a discriminant cut-off score=0 (i.e. less than 0 indicated liver cirrhosis and greater than 0 indicated CHC without cirrhosis) with high degrees of specificity (97%), positive predictive value (99%) and negative predictive value (92%). The MDA of the absolute values of a combination of four routine tests can efficiently indicate liver cirrhosis in CHC patients. Based on individual patient MDA score value, each patient can be simply and efficiently classified into a cirrhotic or a non-cirrhotic liver patient.

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