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De Rosa FG, Pucillo LP, Casato M, et al. Myths, misconceptions and mixed cryoglobulinemia associated with HCV infection. Minerva Gastroenterol Dietol. 2002;48(4):319-29
De Rosa, F. G., Pucillo, L. P., Casato, M., & Agnello, V. (2002). Myths, misconceptions and mixed cryoglobulinemia associated with HCV infection. Minerva gastroenterologica e dietologica, 48(4), 319-29.
De Rosa, F G, et al. "Myths, misconceptions and mixed cryoglobulinemia associated with HCV infection." Minerva gastroenterologica e dietologica vol. 48,4 (2002): 319-29.
De Rosa FG, Pucillo LP, Casato M, Agnello V. Myths, misconceptions and mixed cryoglobulinemia associated with HCV infection. Minerva Gastroenterol Dietol. 2002 Dec;48(4):319-29. PMID: 16491057.
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Minerva Gastroenterol Dietol. 2002 Dec;48(4):319-29.

Myths, misconceptions and mixed cryoglobulinemia associated with HCV infection.

Minerva gastroenterologica e dietologica

F G De Rosa, L P Pucillo, M Casato, V Agnello

Affiliations

  1. Department of Infectious Diseases, University of Turin, Turin, Italy.

PMID: 16491057

Abstract

The delineation of the association of HCV infection with mixed cryoglobulinemia has provided new insight into the etiology and pathogenesis of this extrahepatic manifestation of the infection. Yet very little evidence has been obtained thus far on the specific roles of virus in production of the monoclonal rheumatoid factors responsible for classic type II cryoglobulins and the associated clinical manifestations. The problematic areas of investigation that have in some instances generated misconceptions due to lack of data are reviewed. These include the prevalence and heterogeneity of mixed cryoglobulins; clinical manifestations such as liver cirrhosis, membranoproliferative glomerulonephritis, autoimmunity, progression of cryoglobulinemia from type III to type II, development of B cell malignancies; determination of lineages based on immunoglobulin gene utilization; and the anti-viral treatment of patients with mixed cryoglobulinemia.

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